Ross Malcolm, Hadzikadic Gusic Lejla, Dabbs David J, Kelley Joseph, Diego Emilia
Tumori. 2014 Jul-Aug;100(4):136e-9e. doi: 10.1700/1636.17928.
Nodal patterns of spread for breast cancer and melanoma have been extensively studied in the literature. The phenomenon of upper extremity melanoma and ipsilateral breast cancer has been previously reported. We describe a rare case of a simultaneous locoregional recurrence of both malignancies.
A patient with a previous diagnosis of stage 1A melanoma of the left upper extremity at age 29 developed left breast invasive ductal carcinoma 1 year later. The patient underwent a wide local excision with negative margins for the melanoma and a partial mastectomy with axillary dissection followed by chemotherapy and radiation therapy for her breast cancer. Five years later she was diagnosed with a dual recurrence while 36 weeks pregnant.
Regular follow-up according to the NCCN guidelines is critical in diagnosing a recurrence of malignancy. Pathologic analysis is paramount in dictating management strategies in rare cases of dual recurrence.
乳腺癌和黑色素瘤的淋巴结转移模式在文献中已有广泛研究。上肢黑色素瘤和同侧乳腺癌的现象此前已有报道。我们描述了一例两种恶性肿瘤同时局部区域复发的罕见病例。
一名29岁曾被诊断为左上肢1A期黑色素瘤的患者，1年后发生左乳腺浸润性导管癌。该患者接受了黑色素瘤的广泛局部切除且切缘阴性，以及乳腺癌的保乳手术加腋窝清扫，随后接受了化疗和放疗。五年后，她在怀孕36周时被诊断为双复发。
根据美国国立综合癌症网络（NCCN）指南进行定期随访对于诊断恶性肿瘤复发至关重要。在罕见的双复发病例中，病理分析对于制定治疗策略至关重要。
