Xu Zi, Liu Shangyuan, Wang Huijie, Gao Guofen, Yu Peng, Chang Yanzhong
Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, Hebei Province, People's Republic of China.
Biol Trace Elem Res. 2014 Dec;162(1-3):181-8. doi: 10.1007/s12011-014-0143-0. Epub 2014 Oct 9.
To investigate the effect of iron liposome supplementation, a rat model of exercise-associated anemia was established by subjecting the animals to high-intensity running exercises for 4 weeks. Rats with confirmed anemia were strenuously exercised for another 2 weeks while receiving iron supplements by intragastric administration of ferric ammonium citrate (FAC) liposomes or heme iron liposomes. Control groups were administered equivalent amounts of FAC, heme iron, or blank liposomes. Subsequently, complete blood count (CBC), serum iron, and liver iron levels were tested to determine the efficiency of iron liposomes in relieving anemia. Superoxide dismutase (SOD) and malonyldialdehyde (MDA) were also detected to determine potential side effects of iron supplementation. The CBC, as well as serum iron and liver iron contents, significantly increased and reached much higher levels in anemic rats treated with iron liposomes, compared with those of control groups. The increase of SOD and decrease of MDA levels were also observed after supplementation with iron liposomes. These results demonstrate that iron liposomes can efficiently relieve the iron deficiency in strenuously exercised rats and may potentially be used as a supplement for the treatment of exercise-associated iron deficiency anemia with minimal side effects.
为了研究补充铁脂质体的效果，通过让动物进行4周的高强度跑步运动，建立了运动性贫血大鼠模型。确诊为贫血的大鼠在另外2周内进行剧烈运动，同时通过胃内给予柠檬酸铁铵（FAC）脂质体或血红素铁脂质体来补充铁。对照组给予等量的FAC、血红素铁或空白脂质体。随后，检测全血细胞计数（CBC）、血清铁和肝脏铁水平，以确定铁脂质体缓解贫血的效果。还检测了超氧化物歧化酶（SOD）和丙二醛（MDA），以确定补充铁的潜在副作用。与对照组相比，用铁脂质体治疗的贫血大鼠的CBC以及血清铁和肝脏铁含量显著增加，并达到更高水平。补充铁脂质体后还观察到SOD增加和MDA水平降低。这些结果表明，铁脂质体可以有效缓解剧烈运动大鼠的缺铁状况，并可能潜在地用作治疗运动性缺铁性贫血的补充剂，且副作用最小。
