Ahmed Samia A, Hamed Manal A, Omar Omar S
Therapeutic Chemistry Department, National Research Centre, El-Bohooth St., Dokki, Cairo, Egypt.
Tumour Biol. 2015 Feb;36(2):815-22. doi: 10.1007/s13277-014-2689-z. Epub 2014 Oct 9.
The objective of this study is to explore and correlate the value of certain biomarkers in breast cancer (BC) females with and without metastasis after undergoing the surgical treatment protocol in the National Cancer Institute in Egypt. Thirty females (33-69 years), diagnosed as early breast cancer patients with or without metastasis, and 20 healthy individuals were selected for this study. The biomarkers under investigation were vascular endothelial growth factor (VEGF), C-reactive protein (CRP), interleukin-6 (IL-6), and interleukin-8 (IL-8). The correlation between these markers and the tumor grade was also evaluated. The results revealed a significant increase (p < 0.0001) in VEGF, CRP, IL-6, and IL-8 in breast cancer patients with or without metastasis as compared to the healthy group. Surgical treatment of metastatic BC females showed a significant reduction of those parameters by variable degrees, whereas BC females without metastasis recorded the most inhibition levels. Also, there was positive correlation (p < 0.0001) between those biomarkers and the tumor grades. We also noticed an association between VEGF and IL-8 as well as CRP and IL-6. In conclusion, the selected biomarkers may be beneficial for the prognosis of breast cancer and seem to be a diagnostic tool to differentiate between BC with or without metastasis. The descried surgical treatment protocol succeeded to attenuate the elevated biomarker levels and improve patient survival which deserves more extensive studies.
本研究的目的是探究并关联埃及国家癌症研究所接受手术治疗方案的有转移和无转移乳腺癌（BC）女性中某些生物标志物的价值。本研究选取了30名女性（33 - 69岁），她们被诊断为有或无转移的早期乳腺癌患者，以及20名健康个体。所研究的生物标志物包括血管内皮生长因子（VEGF）、C反应蛋白（CRP）、白细胞介素-6（IL-6）和白细胞介素-8（IL-8）。还评估了这些标志物与肿瘤分级之间的相关性。结果显示，与健康组相比，有或无转移的乳腺癌患者的VEGF、CRP、IL-6和IL-8均显著升高（p < 0.0001）。转移性BC女性的手术治疗使这些参数在不同程度上显著降低，而无转移的BC女性记录的抑制水平最高。此外，这些生物标志物与肿瘤分级之间存在正相关（p < 0.0001）。我们还注意到VEGF与IL-8以及CRP与IL-6之间存在关联。总之，所选生物标志物可能有助于乳腺癌的预后评估，似乎是区分有转移和无转移BC的诊断工具。所描述的手术治疗方案成功降低了升高的生物标志物水平并提高了患者生存率，这值得更广泛的研究。
