Kobayashi Masayoshi, Sugimoto Masayuki, Komori Kimihiro
Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, Nagoya University.
Circ J. 2014;78(12):2819-26. doi: 10.1253/circj.cj-14-0656. Epub 2014 Oct 8.
Buerger's disease (thromboangiitis obliterans) is considered to be a nonatherosclerotic, inflammatory, and vaso-occlusive disease, although the details of the mechanisms of pathogenesis remain unknown. The occurrence of the disease is strongly related to tobacco abuse and its progression is closely linked to continued smoking. The purpose of this review article is to demonstrate the pathological characteristics of arteries affected with Buerger's disease from a possible immunoreactive point of view. In addition, we present the mechanisms for preserving the architecture of the arterial wall in affected vasculatures. Thereafter, we discuss the possibility that the pathogenesis of Buerger's disease is a type of endarteritis obliterans, deeply connected to the Notch pathway, distinct from arteriosclerosis obliterans and other vasculitides.
血栓闭塞性脉管炎被认为是一种非动脉粥样硬化性、炎症性和血管闭塞性疾病，尽管其发病机制的细节仍不清楚。该疾病的发生与烟草滥用密切相关，其进展与持续吸烟紧密相连。这篇综述文章的目的是从可能的免疫反应角度阐述受血栓闭塞性脉管炎影响的动脉的病理特征。此外，我们还介绍了在受影响的脉管系统中维持动脉壁结构的机制。此后，我们讨论了血栓闭塞性脉管炎的发病机制是一种与Notch通路深度相关的闭塞性动脉内膜炎的可能性，它不同于动脉硬化闭塞症和其他血管炎。
