Sellers Eric W, Ryan David B, Hauser Christopher K
Department of Psychology, East Tennessee State University, Johnson City, TN 37614, USA.
Department of Psychology, East Tennessee State University, Johnson City, TN 37614, USA. Department of Neurobiology and Anatomy, Wake Forest University, Winston Salem, NC 27106, USA.
Sci Transl Med. 2014 Oct 8;6(257):257re7. doi: 10.1126/scitranslmed.3007801.
Brain-computer interfaces (BCIs) provide communication that is independent of muscle control, and can be especially important for individuals with severe neuromuscular disease who cannot use standard communication pathways or other assistive technology. It has previously been shown that people with amyotrophic lateral sclerosis (ALS) can successfully use BCI after all other means of independent communication have failed. The BCI literature has asserted that brainstem stroke survivors can also benefit from BCI use. This study used a P300-based event-related potential spelling system. This case study demonstrates that an individual locked-in owing to brainstem stroke was able to use a noninvasive BCI to communicate volitional messages. Over a period of 13 months, the participant was able to successfully operate the system during 40 of 62 recording sessions. He was able to accurately spell words provided by the experimenter and to initiate dialogues with his family. The results broadly suggest that, regardless of the precipitating event, BCI use may be of benefit to those with locked-in syndrome.
脑机接口（BCIs）提供独立于肌肉控制的通信方式，对于患有严重神经肌肉疾病、无法使用标准通信途径或其他辅助技术的个体而言，可能尤为重要。此前已有研究表明，肌萎缩侧索硬化症（ALS）患者在所有其他独立通信方式均告失败后，能够成功使用脑机接口。脑机接口相关文献称，脑干卒中幸存者也能从使用脑机接口中获益。本研究采用了基于P300的事件相关电位拼写系统。该案例研究表明，一名因脑干卒中而闭锁综合征的个体能够使用非侵入性脑机接口来传达意愿信息。在13个月的时间里，该参与者在62次记录会话中的40次中成功操作了该系统。他能够准确拼写出实验者提供的单词，并与家人展开对话。研究结果大致表明，无论引发事件如何，使用脑机接口可能对闭锁综合征患者有益。
