血红蛋白“希望”：一种罕见的血红蛋白变体——免疫比浊法检测中糖化血红蛋白水平升高的原因
Hb Hope: A Rare Variant of Haemoglobin-Forged a Rise in HbA1c on Immunoturbidimetric Assay.
作者信息
Singh Bratati, Behera Debasis Debadatta, Mehta Neelam, Das Seema
机构信息
Department of Biochemistry, IMS & SUM Hospital, Sikshya O Anusandhan University, Bhubaneswar, Odisha India.
出版信息
Indian J Clin Biochem. 2014 Oct;29(4):517-9. doi: 10.1007/s12291-013-0406-0. Epub 2013 Dec 3.
Abstract
Glycosylated hemoglobin (HbA1c) determination is a powerful means for assessing the evaluation and management of patients with diabetes mellitus. Hemoglobin (Hb) variants and chemically modified derivatives of Hb can affect the accuracy of measurement of HbA1c done by various analytical methods. We report a patient with a rare variant of Hb (Hb Hope) that caused an abnormally high value of HBA1c when assayed using immunoturbidimetric assay ("Tina-quant" 2nd generation assay) and also elucidate the nature of the variant.
摘要
糖化血红蛋白（HbA1c）测定是评估和管理糖尿病患者的有力手段。血红蛋白（Hb）变体和Hb的化学修饰衍生物会影响通过各种分析方法测定HbA1c的准确性。我们报告了一名患有罕见Hb变体（Hb Hope）的患者，该变体在使用免疫比浊法（“Tina-quant”第二代检测法）检测时导致HbA1c值异常升高，并阐明了该变体的性质。
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