血红蛋白E病与糖化血红蛋白
Hemoglobin E disease and glycosylated hemoglobin.
作者信息
Yedla Niharika, Kuchay Mohammad Shafi, Mithal Ambrish
机构信息
Department of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.
出版信息
Indian J Endocrinol Metab. 2015 Sep-Oct;19(5):683-5. doi: 10.4103/2230-8210.163211.
Abstract
Glycosylated hemoglobin (HbA1C) is a routinely measured parameter to monitor long-term glycemic control in people with diabetes mellitus. The presence of hemoglobin (Hb) variants can affect the accuracy of HbA1C methods. Hb E variant is the most common Hb variant in South-east Asia and North-east India. In the presence of Hb E, HbA1C may not be detectable by ion-exchange chromatography (high-pressure liquid chromatography), but may be estimated by immunoassay technique and boronate affinity chromatography. However, the result may be underestimated when correlated with plasma glucose and serum fructosamine levels. Clinicians should be aware of this limitation of HbA1C estimation in patients with Hb E and other Hb variants.
摘要
糖化血红蛋白（HbA1C）是用于监测糖尿病患者长期血糖控制情况的常规测量参数。血红蛋白（Hb）变体的存在会影响HbA1C检测方法的准确性。Hb E变体是东南亚和印度东北部最常见的Hb变体。在存在Hb E的情况下，离子交换色谱法（高压液相色谱法）可能无法检测到HbA1C，但可通过免疫测定技术和硼酸亲和色谱法进行估算。然而，与血浆葡萄糖和血清果糖胺水平相关时，结果可能会被低估。临床医生应了解Hb E和其他Hb变体患者中HbA1C估算的这一局限性。
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