酷似肉瘤的结外间变性大细胞淋巴瘤：1例有趣病例报告

Jairajpuri Zeeba S, Rana Safia, Khetrapal Shaan, Talikoti Majid A, Jetley Sujata

Department of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.

Department of Surgery, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.

Int J Appl Basic Med Res. 2014 Sep;4(Suppl 1):S50-2. doi: 10.4103/2229-516X.140741.

Lymphomas are malignancies of the lymphoid tissues involving cells of the immune system. Primary systemic anaplastic large cell lymphoma (ALCL) represents an aggressive lymphoma characterized by neoplastic proliferation of lymphoid cells with an anaplastic appearance. Large pleomorphic cells are "hallmark" cells with horseshoe-shaped or kidney-shaped nuclei and a constant expression of the CD30 molecule on all neoplastic cells. There is a vast morphological spectrum posing a challenge to pathologists in the diagnosis of ALCL.

淋巴瘤是涉及免疫系统细胞的淋巴组织恶性肿瘤。原发性系统性间变性大细胞淋巴瘤（ALCL）是一种侵袭性淋巴瘤，其特征为具有间变外观的淋巴样细胞的肿瘤性增殖。大的多形性细胞是“标志性”细胞，具有马蹄形或肾形细胞核，并且所有肿瘤细胞上均持续表达CD30分子。存在广泛的形态学谱，这给病理学家诊断ALCL带来了挑战。