Wingren Carl Johan, Ottosson Anders
Department of Forensic Medicine in Lund, The National Board of Forensic Medicine, Sölvegatan 25, SE-223 62 Lund, Sweden; Unit for Forensic Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
Department of Forensic Medicine in Lund, The National Board of Forensic Medicine, Sölvegatan 25, SE-223 62 Lund, Sweden; Unit for Forensic Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
Forensic Sci Int. 2014 Nov;244:285-8. doi: 10.1016/j.forsciint.2014.09.012. Epub 2014 Sep 28.
Obesity is a global problem and in aspects of lethal ethanol intoxications virtually unexplored. The cause of death in ethanol intoxication is generally considered to be suppression of the respiratory function. Previous research indicates that respiratory function is more vulnerable in obese subjects than in those of normal weight. We hypothesized that lethal blood alcohol concentration (BAC) is lower in obese subjects compared to those of normal weight. We used the Swedish medicolegal autopsy register and identified all medicolegal autopsy cases in Sweden during the period from 1999 to 2013 (N=79,060), and identified 1545 cases with ethanol intoxication identified as the primary cause of death. We studied the association between body mass index and lethal BAC using logistic regression models that we adjusted using several potential confounders such as age, sex, drugs, and extent of decomposition. We observed an association between obesity and lower lethal BACs. The estimated adjusted odds ratio of the association between obesity and a lethal BAC >3‰, using subjects of normal weight as reference, was 0.54, 95% confidence interval: 0.39-0.74. The result indicates that in obese subjects the lethal BAC is lower than in those of normal weight.
肥胖是一个全球性问题，而在致死性乙醇中毒方面几乎未被探索。乙醇中毒的死因通常被认为是呼吸功能抑制。先前的研究表明，肥胖者的呼吸功能比正常体重者更脆弱。我们假设，与正常体重者相比，肥胖者的致死血液酒精浓度（BAC）更低。我们使用了瑞典法医学尸检登记册，确定了1999年至2013年期间瑞典所有的法医学尸检病例（N = 79,060），并确定了1545例以乙醇中毒为主要死因的病例。我们使用逻辑回归模型研究了体重指数与致死BAC之间的关联，并使用年龄、性别、药物和尸体腐败程度等几个潜在混杂因素进行了调整。我们观察到肥胖与较低的致死BAC之间存在关联。以正常体重者为参照，肥胖与致死BAC>3‰之间关联的估计调整比值比为0.54，95%置信区间：0.39 - 0.74。结果表明，肥胖者的致死BAC低于正常体重者。
