记忆形成的神经生物学基础：从生理状况到精神病理学
The neurobiological bases of memory formation: from physiological conditions to psychopathology.
作者信息
Bisaz Reto, Travaglia Alessio, Alberini Cristina M
机构信息
Center for Neural Science, New York University, New York, N.Y., USA.
出版信息
Psychopathology. 2014;47(6):347-56. doi: 10.1159/000363702. Epub 2014 Oct 3.
Abstract
The formation of long-term memories is a function necessary for an adaptive survival. In the last two decades, great progress has been made in the understanding of the biological bases of memory formation. The identification of mechanisms necessary for memory consolidation and reconsolidation, the processes by which the posttraining and postretrieval fragile memory traces become stronger and insensitive to disruption, has indicated new approaches for investigating and treating psychopathologies. In this review, we will discuss some key biological mechanisms found to be critical for memory consolidation and strengthening, the role/s and mechanisms of memory reconsolidation, and how the interference with consolidation and/or reconsolidation can modulate the retention and/or storage of memories that are linked to psychopathologies.
摘要
长期记忆的形成是适应性生存所必需的一项功能。在过去二十年里，我们对记忆形成的生物学基础的理解取得了巨大进展。记忆巩固和再巩固机制的确定，即训练后和检索后脆弱的记忆痕迹变得更强且对干扰不敏感的过程，为研究和治疗精神病理学指明了新方法。在这篇综述中，我们将讨论一些被发现对记忆巩固和强化至关重要的关键生物学机制、记忆再巩固的作用和机制，以及对巩固和/或再巩固的干扰如何调节与精神病理学相关的记忆的保持和/或存储。
相似文献
1
The neurobiological bases of memory formation: from physiological conditions to psychopathology.记忆形成的神经生物学基础：从生理状况到精神病理学
Psychopathology. 2014;47(6):347-56. doi: 10.1159/000363702. Epub 2014 Oct 3.
2
Stress modulation of reconsolidation.应激调节再巩固。
Psychopharmacology (Berl). 2013 Apr;226(4):747-61. doi: 10.1007/s00213-012-2887-6. Epub 2012 Oct 6.
3
The role of reconsolidation and the dynamic process of long-term memory formation and storage.重新巩固的作用以及长期记忆形成与存储的动态过程。
Front Behav Neurosci. 2011 Mar 7;5:12. doi: 10.3389/fnbeh.2011.00012. eCollection 2011.
4
Pharmacological manipulation of memory reconsolidation: towards a novel treatment of pathogenic memories.记忆再巩固的药理学调控：迈向对病理性记忆的新型治疗
Eur J Pharmacol. 2008 May 13;585(2-3):453-7. doi: 10.1016/j.ejphar.2008.03.010. Epub 2008 Mar 18.
5
Post-retrieval extinction as reconsolidation interference: methodological issues or boundary conditions?提取后消退作为再巩固干扰：方法学问题还是边界条件？
Psychopharmacology (Berl). 2013 Apr;226(4):631-47. doi: 10.1007/s00213-013-3004-1. Epub 2013 Feb 13.
6
Postretrieval Relearning Strengthens Hippocampal Memories via Destabilization and Reconsolidation.检索后再学习通过破坏和再巩固增强海马体记忆。
J Neurosci. 2019 Feb 6;39(6):1109-1118. doi: 10.1523/JNEUROSCI.2618-18.2018. Epub 2018 Dec 26.
7
Linking new information to a reactivated memory requires consolidation and not reconsolidation mechanisms.将新信息与重新激活的记忆相联系需要巩固机制而非重新巩固机制。
PLoS Biol. 2005 Sep;3(9):e293. doi: 10.1371/journal.pbio.0030293. Epub 2005 Aug 23.
8
CCAAT enhancer binding protein δ plays an essential role in memory consolidation and reconsolidation.CCAAT 增强子结合蛋白 δ 在记忆巩固和再巩固中起着至关重要的作用。
J Neurosci. 2013 Feb 20;33(8):3646-58. doi: 10.1523/JNEUROSCI.1635-12.2013.
9
Strengthening a consolidated memory: the key role of the reconsolidation process.强化巩固记忆：再巩固过程的关键作用。
J Physiol Paris. 2014 Sep-Dec;108(4-6):323-33. doi: 10.1016/j.jphysparis.2014.09.001. Epub 2014 Sep 16.
10
Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes?记忆巩固的机制：巩固和重新巩固是相似还是不同的过程？
Trends Neurosci. 2005 Jan;28(1):51-6. doi: 10.1016/j.tins.2004.11.001.
引用本文的文献
1
Memory under siege: the cognitive costs of smoking and vaping.记忆受围攻：吸烟与吸电子烟的认知代价
Brain Behav Immun Health. 2025 Sep 15;49:101102. doi: 10.1016/j.bbih.2025.101102. eCollection 2025 Nov.
2
The clinical implication of β-arrestins-mediated signaling in memory and cognition.β-抑制蛋白介导的信号传导在记忆和认知中的临床意义。
Mol Cell Biochem. 2025 Jul 5. doi: 10.1007/s11010-025-05323-x.
3
Exploring the Connection Between BDNF/TrkB and AC/cAMP/PKA/CREB Signaling Pathways: Potential for Neuroprotection and Therapeutic Targets for Neurological Disorders.探索脑源性神经营养因子/酪氨酸激酶受体B（BDNF/TrkB）与腺苷酸环化酶/环磷酸腺苷/蛋白激酶A/环磷腺苷反应元件结合蛋白（AC/cAMP/PKA/CREB）信号通路之间的联系：神经保护的潜力及神经系统疾病的治疗靶点
Mol Neurobiol. 2025 May 9. doi: 10.1007/s12035-025-05001-5.
4
Slight and hidden hearing loss differentially affect short- and long-term memory in young rats.轻度隐匿性听力损失对幼鼠的短期和长期记忆有不同影响。
Behav Pharmacol. 2025 Aug 1;36(5):300-311. doi: 10.1097/FBP.0000000000000828. Epub 2025 Apr 17.
5
Dual orexin receptor antagonists as promising therapeutics for Alzheimer's disease.双重食欲素受体拮抗剂有望成为治疗阿尔茨海默病的药物。
NPJ Biol Timing Sleep. 2025;2(1):11. doi: 10.1038/s44323-025-00025-5. Epub 2025 Mar 8.
6
Poly ADP-ribosylation regulates Arc expression and promotes adaptive stress-coping.多聚 ADP 核糖基化调节 Arc 表达并促进适应性应激应对。
Psychopharmacology (Berl). 2025 Apr;242(4):741-750. doi: 10.1007/s00213-025-06744-8. Epub 2025 Jan 14.
7
The Role of Cells in Encoding and Storing Information: A Narrative Review of Cellular Memory.细胞在编码和存储信息中的作用：细胞记忆的叙述性综述
Cureus. 2024 Nov 5;16(11):e73063. doi: 10.7759/cureus.73063. eCollection 2024 Nov.
8
Analysis of Differential microRNA Expression in the Hippocampus of Scopolamine-Induced Amnesic Mouse Model.东莨菪碱诱导的失忆小鼠模型海马中差异微小RNA表达的分析
Mol Neurobiol. 2025 Apr;62(4):4881-4898. doi: 10.1007/s12035-024-04573-y. Epub 2024 Nov 4.
9
A Nanobody-Based Proximity Ligation Assay Detects Constitutive and Stimulus-Regulated Native Arc/Arg3.1 Oligomers in Hippocampal Neuronal Dendrites.基于纳米抗体的邻近连接分析检测海马神经元树突中组成型和刺激调节型天然Arc/Arg3.1寡聚体。
Mol Neurobiol. 2025 Apr;62(4):3973-3990. doi: 10.1007/s12035-024-04508-7. Epub 2024 Oct 5.
10
The Dynamic Relationship between the Glymphatic System, Aging, Memory, and Sleep.脑淋巴系统、衰老、记忆与睡眠之间的动态关系。
Biomedicines. 2023 Jul 25;11(8):2092. doi: 10.3390/biomedicines11082092.
本文引用的文献
1
Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.在再巩固期间对记忆更新进行表观遗传启动，以减弱远程恐惧记忆。
Cell. 2014 Jan 16;156(1-2):261-76. doi: 10.1016/j.cell.2013.12.020.
2
The endocannabinoid system: an emotional buffer in the modulation of memory function.内源性大麻素系统：记忆功能调节中的一种情绪缓冲器。
Neurobiol Learn Mem. 2014 Jul;112:30-43. doi: 10.1016/j.nlm.2013.12.010. Epub 2013 Dec 29.
3
Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies.长期记忆中的应激与糖皮质激素受体依赖性机制：从适应性反应到精神病理学
Neurobiol Learn Mem. 2014 Jul;112:17-29. doi: 10.1016/j.nlm.2013.09.017. Epub 2013 Oct 7.
4
Memory reconsolidation.记忆再巩固。
Curr Biol. 2013 Sep 9;23(17):R746-50. doi: 10.1016/j.cub.2013.06.046.
5
The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder (PTSD).内源性大麻素系统作为治疗创伤后应激障碍（PTSD）认知和情绪特征的潜在靶点。
Front Behav Neurosci. 2013 Aug 9;7:100. doi: 10.3389/fnbeh.2013.00100. eCollection 2013.
6
Foundations of posttraumatic stress disorder: does early life trauma lead to adult posttraumatic stress disorder?创伤后应激障碍的基础：早期生活创伤是否会导致成人创伤后应激障碍？
Dev Psychopathol. 2011 May;23(2):477-91. doi: 10.1017/S0954579411000186.
7
CCAAT enhancer binding protein δ plays an essential role in memory consolidation and reconsolidation.CCAAT 增强子结合蛋白 δ 在记忆巩固和再巩固中起着至关重要的作用。
J Neurosci. 2013 Feb 20;33(8):3646-58. doi: 10.1523/JNEUROSCI.1635-12.2013.
8
Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation.糖皮质激素受体招募 CaMKIIα-BDNF-CREB 通路来介导记忆巩固。
Nat Neurosci. 2012 Dec;15(12):1707-14. doi: 10.1038/nn.3266. Epub 2012 Nov 18.
9
Mechanisms of memory enhancement.记忆增强的机制。
Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb;5(1):37-53. doi: 10.1002/wsbm.1196. Epub 2012 Nov 13.
10
Biological studies of post-traumatic stress disorder.创伤后应激障碍的生物学研究。
Nat Rev Neurosci. 2012 Nov;13(11):769-87. doi: 10.1038/nrn3339. Epub 2012 Oct 10.
Zotero 插件