Forcato Cecilia, Fernandez Rodrigo S, Pedreira María E
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE - CONICET, Ciudad Universitaria, Pab. II (1428) Buenos Aires, Argentina; Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany.
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE - CONICET, Ciudad Universitaria, Pab. II (1428) Buenos Aires, Argentina.
J Physiol Paris. 2014 Sep-Dec;108(4-6):323-33. doi: 10.1016/j.jphysparis.2014.09.001. Epub 2014 Sep 16.
The reconsolidation hypothesis posits that the presentation of a specific cue, previously associated with a life event, makes the stored memory pass from a stable to a reactivated state. In this state, memory is again labile and susceptible to different agents, which may either damage or improve the original memory. Such susceptibility decreases over time and leads to a re-stabilization phase known as reconsolidation process. This process has been assigned two biological roles: memory updating, which suggests that destabilization of the original memory allows the integration of new information into the background of the original memory; and memory strengthening, which postulates that the labilization-reconsolidation process strengthens the original memory. The aim of this review is to analyze the strengthening as an improvement obtained only by triggering such process without any other treatment. In our lab, we have demonstrated that when triggering the labilization-reconsolidation process at least once the original memory becomes strengthened and increases its persistence. We have also shown that repeated labilization-reconsolidation processes strengthened the original memory by enlarging its precision, and said reinforced memories were more resistant to interference. Finally, we have shown that the strengthening function is not operative in older memories. We present and discuss both our findings and those of others, trying to reveal the central role of reconsolidation in the modification of stored information.
重新巩固假说认为,呈现一个先前与生活事件相关联的特定线索,会使存储的记忆从稳定状态转变为重新激活状态。在这种状态下,记忆再次变得不稳定,容易受到不同因素的影响,这些因素可能会损害或改善原始记忆。这种易感性会随着时间的推移而降低,并导致一个称为重新巩固过程的重新稳定阶段。这个过程被赋予了两个生物学作用:记忆更新,这表明原始记忆的不稳定允许新信息整合到原始记忆的背景中;以及记忆强化,这假定不稳定 - 重新巩固过程会强化原始记忆。本综述的目的是分析仅通过触发此过程而不进行任何其他治疗所获得的强化作为一种改善。在我们的实验室中,我们已经证明,当至少触发一次不稳定 - 重新巩固过程时,原始记忆会得到强化并增加其持久性。我们还表明,重复的不稳定 - 重新巩固过程通过扩大其精度来强化原始记忆,并且所述强化后的记忆对干扰更具抵抗力。最后,我们已经表明强化功能在较旧的记忆中不起作用。我们展示并讨论了我们自己以及其他人的研究结果,试图揭示重新巩固在存储信息修改中的核心作用。