Misra Satya Ranjan, Mishra Lora, Mohanty Neeta, Mohanty Susant
Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
BMJ Case Rep. 2014 Oct 9;2014:bcr2014206721. doi: 10.1136/bcr-2014-206721.
Cherubism is a progressive, hereditary fibro-osseous lesion exclusively affecting the jaw bones. It is caused by the abnormal functioning of osteoblasts and osteoclasts, leading to replacement of normal bone by cellular fibrous tissue and immature bone, which produces painless progressive growth of the jaw, with a round facial appearance. It was first described in 1933 by Jones as 'familial multilocular cystic disease of the jaws'. The term 'cherubism' was later coined to describe the rounded facial appearance resulting from jaw hypertrophy that was reminiscent of cherubs depicted throughout Renaissance art. The bony lesions generally occur at an early age, affect one or both jaws symmetrically, and grow progressively until puberty. Spontaneous regression is seen in most cases, although surgical re-contouring may be required for others for aesthetic reasons.
cherubism是一种进行性遗传性纤维-骨病变，仅累及颌骨。它是由成骨细胞和破骨细胞的异常功能引起的，导致正常骨被细胞纤维组织和未成熟骨替代，从而产生颌骨无痛性进行性生长，面部呈圆形外观。1933年，琼斯首次将其描述为“颌骨家族性多房囊性疾病”。后来创造了“cherubism”这个术语来描述由于颌骨肥大导致的圆形面部外观，这种外观让人联想到文艺复兴时期艺术作品中描绘的小天使。骨病变通常在早年出现，对称累及一侧或双侧颌骨，并逐渐生长直至青春期。大多数情况下会出现自发消退，不过其他一些病例可能出于美学原因需要进行手术重塑轮廓。
