Ohtsubo K, Ryu J C, Nakamura K, Izumiyama N, Tanaka T, Yamamura H, Kobayashi T, Ueno Y
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan.
Food Chem Toxicol. 1989 Sep;27(9):591-8. doi: 10.1016/0278-6915(89)90018-5.
Groups of 42 7-wk-old female C57BL/6CrSlc SPF mice were fed diets containing 0, 6, 12 and 30 ppm nivalenol (NIV) for 2 years. Body-weight gain was reduced in all treated groups of animals and feed efficiency was reduced, significantly so, in the high-dose group. The absolute weights of the liver in the 30-ppm group, and of the kidneys in the 12- and 30-ppm groups were significantly reduced, compared with those of the controls. When expressed relative to brain weight there was a reduction in the kidney weight of the 12-ppm NIV group only. Some leucopenia was seen in the treated mice, particularly in the 30-ppm group, although this was not statistically significant, and there were dose-dependent increases in the serum concentrations of alkaline phosphatase and non-esterified fatty acids. No tumours attributable to NIV were found in any of the experimental groups. Naturally occurring tumours, mostly lymphomas, were of similar incidence in all groups, but developed later and appeared to grow more slowly in the mice of the 30-ppm group than in those of other groups. The incidence of amyloidosis, particularly in the small intestine, was low in the two higher dose groups compared with that in the control group. The mortality rate of the 30-ppm NIV group was lower than that of the control group and this may be partly due to the lower tumour incidence in the earlier period and partly due to the lower incidence of amyloidosis.
将42只7周龄的雌性C57BL/6CrSlc无特定病原体小鼠分为几组，分别喂食含0、6、12和30 ppm雪腐镰刀菌烯醇（NIV）的饲料，持续2年。所有接受处理的动物组体重增加均减少，高剂量组的饲料效率显著降低。与对照组相比，30 ppm组肝脏的绝对重量以及12 ppm和30 ppm组肾脏的绝对重量均显著降低。仅在12 ppm NIV组中，以相对于脑重表示时肾脏重量有所减少。在接受处理的小鼠中观察到一些白细胞减少，尤其是在30 ppm组中，尽管这在统计学上不显著，并且碱性磷酸酶和非酯化脂肪酸的血清浓度呈剂量依赖性增加。在任何实验组中均未发现由NIV引起的肿瘤。自然发生的肿瘤，主要是淋巴瘤，在所有组中的发生率相似，但在30 ppm组的小鼠中比其他组出现得更晚，且生长似乎更缓慢。与对照组相比，两个高剂量组中淀粉样变性的发生率，尤其是在小肠中的发生率较低。30 ppm NIV组的死亡率低于对照组，这可能部分归因于早期较低的肿瘤发生率，部分归因于淀粉样变性的较低发生率。
