在对三硝基苯（TNP）的接触性敏感反应中，抗原特异性抑制白细胞介素-2和白细胞介素-3的产生。

Antigen-specific inhibition of IL-2 and IL-3 production in contact sensitivity to TNP.

作者信息

Marcinkiewicz J, Chain B

机构信息

Department of Immunology, N. Copernicus Medical Academy, Cracow, Poland.

出版信息

Immunology. 1989 Oct;68(2):185-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1385414/

Abstract

The production of IL-2 and IL-3 by T cells from mice which had been contact sensitized to TNP and/or tolerized by intravenous injections of TNBS was assayed. Contact sensitization rapidly primes T cells, so that they respond to in vitro restimulation with haptenated syngeneic cells by producing IL-2 and IL-3. This production is strongly inhibited, in an antigen-specific manner, in tolerized mice. At least part of this inhibition can be attributed to the action of suppressor T cells that act by preventing the activation of lymphokine production in vitro. Lymphokine production thus closely parallels the in vivo delayed-type hypersensitivity (DTH) reaction in this system.

摘要

对三硝基苯（TNP）进行接触致敏和/或通过静脉注射三硝基苯磺酸（TNBS）进行耐受处理的小鼠的T细胞中白细胞介素-2（IL-2）和白细胞介素-3（IL-3）的产生情况进行了测定。接触致敏能迅速使T细胞致敏，从而使其在体外受到半抗原化的同基因细胞再次刺激时通过产生IL-2和IL-3做出反应。在耐受处理的小鼠中，这种产生以抗原特异性的方式受到强烈抑制。这种抑制至少部分可归因于抑制性T细胞的作用，这些抑制性T细胞通过阻止体外淋巴因子产生的激活发挥作用。因此，在该系统中，淋巴因子的产生与体内迟发型超敏反应（DTH）密切平行。

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