Dwyer J M, Kantor F S
J Exp Med. 1973 Jan 1;137(1):32-41. doi: 10.1084/jem.137.1.32.
Two potential mechanisms for terminating delayed hypersensitivity (DH) reactions have been examined in desensitized guinea pigs. Lack of macrophage responsiveness to lymphokines was sought as an explanation for the reduced ability of these animals to express delayed hypersensitivity. Skin-reactive factor was injected into the skin of desensitized guinea pigs and a control group of similarly immunized animals. The resulting inflammatory reactions were similar in size and intensity in both groups indicating normal macrophage responsiveness in the desensitized state. Passive cellular transfer of DH responses to desensitized animals was markedly less successful than transfer to normal animals. However, cells from desensitized guinea pigs did transfer DH responsiveness to normal animals. These data support the concept of a humoral suppressant of cellular immunity, perhaps acting as a feedback inhibitor, produced when guinea pigs are desensitized.
在脱敏豚鼠中研究了终止迟发型超敏反应（DH）的两种潜在机制。研究人员试图寻找巨噬细胞对淋巴因子反应性缺乏的原因，以解释这些动物表达迟发型超敏反应能力降低的现象。将皮肤反应因子注射到脱敏豚鼠以及一组同样免疫的对照动物的皮肤中。两组动物所产生的炎症反应在大小和强度上相似，表明脱敏状态下巨噬细胞反应正常。将DH反应被动细胞转移至脱敏动物比转移至正常动物明显更不成功。然而，来自脱敏豚鼠的细胞确实能将DH反应性转移至正常动物。这些数据支持了一种细胞免疫体液抑制因子的概念，这种因子可能作为一种反馈抑制剂，在豚鼠脱敏时产生。
