迟发型超敏反应的调节。无法将迟发型超敏反应转移至脱敏豚鼠。
Regulation of delayed hypersensitivity. Failure to transfer delayed hypersensitivity to desensitized guinea pigs.
作者信息
Dwyer J M, Kantor F S
出版信息
J Exp Med. 1973 Jan 1;137(1):32-41. doi: 10.1084/jem.137.1.32.
Abstract
Two potential mechanisms for terminating delayed hypersensitivity (DH) reactions have been examined in desensitized guinea pigs. Lack of macrophage responsiveness to lymphokines was sought as an explanation for the reduced ability of these animals to express delayed hypersensitivity. Skin-reactive factor was injected into the skin of desensitized guinea pigs and a control group of similarly immunized animals. The resulting inflammatory reactions were similar in size and intensity in both groups indicating normal macrophage responsiveness in the desensitized state. Passive cellular transfer of DH responses to desensitized animals was markedly less successful than transfer to normal animals. However, cells from desensitized guinea pigs did transfer DH responsiveness to normal animals. These data support the concept of a humoral suppressant of cellular immunity, perhaps acting as a feedback inhibitor, produced when guinea pigs are desensitized.
摘要
在脱敏豚鼠中研究了终止迟发型超敏反应（DH）的两种潜在机制。研究人员试图寻找巨噬细胞对淋巴因子反应性缺乏的原因，以解释这些动物表达迟发型超敏反应能力降低的现象。将皮肤反应因子注射到脱敏豚鼠以及一组同样免疫的对照动物的皮肤中。两组动物所产生的炎症反应在大小和强度上相似，表明脱敏状态下巨噬细胞反应正常。将DH反应被动细胞转移至脱敏动物比转移至正常动物明显更不成功。然而，来自脱敏豚鼠的细胞确实能将DH反应性转移至正常动物。这些数据支持了一种细胞免疫体液抑制因子的概念，这种因子可能作为一种反馈抑制剂，在豚鼠脱敏时产生。
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本文引用的文献
1
The compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs.脱敏豚鼠中抗原反应性淋巴细胞的区室化
J Exp Med. 1971 Sep 1;134(3 Pt 1):741-50. doi: 10.1084/jem.134.3.741.
2
HEMAGGLUTINATION REACTIONS OF HUMAN ERYTHROCYTES CONJUGATED COVALENTLY WITH DINITROPHENYL GROUPS.与二硝基苯基基团共价结合的人红细胞的血凝反应。
J Immunol. 1965 Mar;94:317-22.
3
IMMUNOLOGIC UNRESPONSIVENESS TO PROTEIN ANTIGENS INDUCED IN ADULT HYPERSENSITIVE MICE.成年过敏小鼠中诱导产生的对蛋白质抗原的免疫无反应性
J Allergy. 1963 Nov-Dec;34:504-19. doi: 10.1016/0021-8707(63)90092-3.
4
5
Delayed hypersensitivity. III. Specific desensitization of guinea pigs sensitized to protein antigens.迟发型超敏反应。III. 对蛋白质抗原有致敏反应的豚鼠的特异性脱敏
J Exp Med. 1958 Dec 1;108(6):891-904. doi: 10.1084/jem.108.6.891.
6
Release of skin reactive factor from guinea-pig lymphocytes by mitogens.丝裂原刺激豚鼠淋巴细胞释放皮肤反应因子。
Nature. 1970 Jan 17;225(5229):236-8. doi: 10.1038/225236a0.
7
Delayed hypersensitivity and desensitization to chemical haptens: antigenic specificity of delayed hypersensitivity.对化学半抗原的迟发型超敏反应和脱敏：迟发型超敏反应的抗原特异性。
Br Med Bull. 1967 Jan;23(1):21-3. doi: 10.1093/oxfordjournals.bmb.a070509.
8
Reactions in vivo and in vitro produced by a soluble substance associated with delayed-type hypersensitivity.一种与迟发型超敏反应相关的可溶性物质在体内和体外所产生的反应。
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9
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Clin Exp Immunol. 1971 Nov;9(5):595-602.
10
Regulatory effect of antibody on the immune response.抗体对免疫反应的调节作用。
Adv Immunol. 1968;8:81-127. doi: 10.1016/s0065-2776(08)60465-4.
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