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经化学诱变减毒的猪霍乱沙门氏菌疫苗株C500的全基因组序列

Complete Genome Sequence of Salmonella enterica Serovar Choleraesuis Vaccine Strain C500 Attenuated by Chemical Mutation.

作者信息

Li Qiuchun, Hu Yachen, Xu Lijuan, Xie Xiaolei, Tao Mingxin, Jiao Xinan

机构信息

Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China

Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China.

出版信息

Genome Announc. 2014 Oct 9;2(5):e01022-14. doi: 10.1128/genomeA.01022-14.

DOI:10.1128/genomeA.01022-14
PMID:25301657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4192389/
Abstract

Salmonella enterica serovar Choleraesuis strain C500 is a live vaccine attenuated by chemical methods. Here, we report the complete genome sequence of the strain, which may be helpful for elucidating the attenuation mechanism of the vaccine strain.

摘要

肠炎沙门氏菌猪霍乱血清型菌株C500是一株经化学方法减毒的活疫苗。在此，我们报告该菌株的完整基因组序列，这可能有助于阐明疫苗株的减毒机制。

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Complete Genome Sequence of Salmonella enterica Serovar Choleraesuis Vaccine Strain C500 Attenuated by Chemical Mutation.经化学诱变减毒的猪霍乱沙门氏菌疫苗株C500的全基因组序列
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The global burden of nontyphoidal Salmonella gastroenteritis.非伤寒型沙门氏菌肠炎的全球负担。
Clin Infect Dis. 2010 Mar 15;50(6):882-9. doi: 10.1086/650733.
2
Salmonella enterica serovar Choleraesuis derivatives harbouring deletions in rpoS and phoP regulatory genes as vehicles for DNA vaccines.携带 rpoS 和 phoP 调控基因缺失的猪霍乱沙门氏菌血清型衍生物作为 DNA 疫苗载体。
Vet Microbiol. 2010 Feb 24;141(1-2):81-8. doi: 10.1016/j.vetmic.2009.08.006. Epub 2009 Aug 8.
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Nontyphoidal Salmonella serovars cause different degrees of invasive disease globally.非伤寒沙门氏菌血清型在全球范围内引起不同程度的侵袭性疾病。
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4
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Infect Immun. 2008 May;76(5):2157-63. doi: 10.1128/IAI.01495-07. Epub 2008 Feb 11.
5
Evaluation of phoP and rpoS mutants of Salmonella enterica serovar Typhi as attenuated typhoid vaccine candidates: virulence and protective immune responses in intranasally immunized mice.肠炎沙门氏菌伤寒血清型phoP和rpoS突变体作为减毒伤寒疫苗候选株的评价：鼻内免疫小鼠的毒力和保护性免疫反应
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Salmonella enterica serotype Choleraesuis: epidemiology, pathogenesis, clinical disease, and treatment.肠炎沙门氏菌猪霍乱血清型：流行病学、发病机制、临床疾病及治疗
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Attenuation and immunogenicity of Deltacya Deltacrp derivatives of Salmonella choleraesuis in pigs.猪霍乱沙门氏菌Deltacya Deltacrp衍生物在猪体内的减毒作用和免疫原性。
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Safety, efficacy, and duration of immunity induced in swine by use of an avirulent live Salmonella choleraesuis-containing vaccine.使用含无毒活猪霍乱沙门氏菌疫苗在猪体内诱导产生的免疫的安全性、有效性和持续时间。
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Characterization and protective properties of attenuated mutants of Salmonella choleraesuis.猪霍乱沙门氏菌减毒突变体的特性及保护特性
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