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上颌骨后部棕色瘤伴多指、并指及心脏异常:一例独特病例报告

Brown tumour of posterior maxilla associated with polydactyly, syndactyly and cardiac anomalies: a unique case report.

作者信息

K V Suresh, Nilesh Kumar, Kumar C D Mounesh, Patil Manisha R, R C Pramod

机构信息

Senior Lecturer, Department of Oral Medicine and Radiology, School of Dental Sciences, Krishna Institute of Medical Sciences, Deemed University, Karad , Satara, Maharashtra, India .

Reader, Department of Oral and Maxillofacial Surgery, School of Dental Sciences, Krishna Institute of Medical Sciences, Deemed University , Karad, Satara, Maharashtra, India .

出版信息

J Clin Diagn Res. 2014 Aug;8(8):ZD31-3. doi: 10.7860/JCDR/2014/9647.4727. Epub 2014 Aug 20.

Abstract

Brown tumour [BT] is an uncommon, non neoplastic complication of Hyperparathyroidism [HPT]. Skeletal changes are the main consequences of this endocrine condition. HPT manifest in three categories. Primary HPT is due to hyperfunction of one or more parathyroid gland, causing an increase of parathyroid hormone secretion resulting in hypercalcemia. Secondary HPT occurs due to chronic renal failure, decreased vitamin D production or with hypocalcemia. Tertiary HPT occurs when the parathyroid activity turns autonomous and excessive, leading to hypercalcemia. BT occurs frequently in the mandible than the maxilla. They are more common in women aged over 50y and majority of BT are asymptomatic. Radiographically, it appears as well defined radioluceny. The gross specimen usually shows a brown or reddish-brown colour. We report a relatively rare combination of maxillary posterior BT as a clinical manifestation of secondary HPT due to vitamin D deficiency with polydactyly, syndactyly and cardiac anomalies.

摘要

棕色瘤[BT]是甲状旁腺功能亢进症[HPT]一种罕见的非肿瘤性并发症。骨骼变化是这种内分泌疾病的主要后果。HPT有三种类型。原发性HPT是由于一个或多个甲状旁腺功能亢进,导致甲状旁腺激素分泌增加,从而引起高钙血症。继发性HPT是由于慢性肾衰竭、维生素D生成减少或低钙血症引起的。当甲状旁腺活动变得自主且过度,导致高钙血症时,就会发生三发性HPT。BT在下颌骨比在上颌骨更常见。它们在50岁以上的女性中更常见,大多数BT是无症状的。在影像学上,它表现为边界清晰的透射区。大体标本通常呈现棕色或红棕色。我们报告了一例相对罕见的上颌后牙区棕色瘤,它是维生素D缺乏继发HPT的临床表现,同时伴有多指畸形、并指畸形和心脏异常。

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