Ward C A, Kalman P G
Department of Mechanical Engineering, University of Toronto, Research Institute, Hospital for Sick Children, Canada.
Med Prog Technol. 1989;15(1-2):63-75.
The possibility has arisen that it is the complement proteins of blood plasma that mediates cellular adhesion following the exposure of a synthetic material to blood. There are two means of investigating this possibility. One is by pharmacologically rendering the complement system of an animal incapable of being activated before its blood is exposed to a material and determining the effect on the degree of cellular adhesion that results. The second is to leave the hemostasis system fully in tact but to modify the material so that the material activates less complement when it is exposed to blood and to determine if this also reduces the degree of cellular adhesion. We review the results of a series of studies that involve both of these approaches. The evidence from both indicate that the complement system mediates cellular adhesion to synthetic materials.
当合成材料接触血液后，有可能是血浆中的补体蛋白介导了细胞黏附。有两种方法来研究这种可能性。一种是通过药理学方法使动物的补体系统在血液接触材料之前无法被激活，然后确定这对由此产生的细胞黏附程度的影响。第二种方法是使止血系统保持完全完整，但对材料进行改性，使其在接触血液时激活的补体较少，并确定这是否也会降低细胞黏附程度。我们回顾了一系列涉及这两种方法的研究结果。来自这两方面的证据都表明补体系统介导了细胞与合成材料的黏附。
