Jak Amy J, Panizzon Matthew S, Spoon Kelly M, Fennema-Notestine Christine, Franz Carol E, Thompson Wesley K, Jacobson Kristen C, Xian Hong, Eyler Lisa T, Vuoksimaa Eero, Toomey Rosemary, Lyons Michael J, Neale Michael C, Tsuang Ming T, Dale Anders M, Kremen William S
Psychology Service, VA San Diego Healthcare System, La Jolla, CA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA; Department of Psychiatry, University of California San Diego, La Jolla, CA.
Department of Psychiatry, University of California San Diego, La Jolla, CA; Twin Research Laboratory, Center for Behavioral Genomics, University of California San Diego, La Jolla, CA.
Am J Geriatr Psychiatry. 2015 May;23(5):456-65. doi: 10.1016/j.jagp.2014.08.011. Epub 2014 Aug 29.
In an effort to address earliest detection of mild cognitive impairment (MCI), we examined hippocampal volumes and atrophy in middle-aged men to explore neuroanatomical support for different neuropsychological definitions of MCI.
460 men aged 51-60 years underwent neuropsychological testing and MRI. MCI was defined according to five criteria sets. MRI-derived hippocampal volume and hippocampal occupancy (HOC) were obtained via FreeSurfer. Statistical analyses were performed using linear mixed models.
Differences in HOC between normal cognitive functioning, amnestic, and non-amnestic MCI were observed using MCI criteria that required one impaired (>1.5 SD) cognitive measure in a given cognitive domain or a cognitive composite score method with a cut-point 2 SD below the mean. Differences in standard hippocampal volume were only found between normal and amnestic presentations and only when using the composite score method.
Results provide empirical support for detection of pre-MCI in younger cohorts. Convergence of neuropsychological and neuroanatomical data, particularly HOC (as opposed to standard cross-sectional volume), supports early identification of MCI as defined by some neuropsychological criteria.
为了努力实现对轻度认知障碍（MCI）的早期检测，我们研究了中年男性的海马体积和萎缩情况，以探索对MCI不同神经心理学定义的神经解剖学支持。
460名年龄在51 - 60岁的男性接受了神经心理学测试和磁共振成像（MRI）检查。MCI根据五套标准进行定义。通过FreeSurfer获得MRI衍生的海马体积和海马占有率（HOC）。使用线性混合模型进行统计分析。
使用要求在给定认知领域有一项受损（>1.5标准差）认知测量指标的MCI标准或切点低于均值2标准差的认知综合评分方法时，观察到正常认知功能、遗忘型和非遗忘型MCI之间HOC的差异。仅在正常和遗忘型表现之间发现了标准海马体积的差异，且仅当使用综合评分方法时。
研究结果为在较年轻队列中检测轻度认知障碍前阶段（pre - MCI）提供了实证支持。神经心理学和神经解剖学数据的一致性，特别是HOC（与标准横断面体积相对），支持了根据某些神经心理学标准定义的MCI的早期识别。
