Peng Jing, Zhang Zhichao, Cui Wanshou, Yuan Yiming, Gao Bing, Song Weidong, Xin Zhongcheng
Andrology Center, Peking University First Hospital, Beijing, China.
Andrology Center, Peking University First Hospital, Beijing, China.
Urology. 2014 Dec;84(6):1389-94. doi: 10.1016/j.urology.2014.08.006. Epub 2014 Oct 11.
To evaluate the results of nocturnal penile erection test and response to daily sildenafil in patients with erectile dysfunction (ED) due to pelvic fracture urethral disruption.
From January 2010 to January 2012, we included 38 patients with ED due to pelvic fracture urethral disruption. The mean age was 33.1 years (range, 22-49 years). All were evaluated subjectively and objectively by the International Index of Erectile Function-5, nocturnal penile tumescence and rigidity (NPTR) test, and penile Doppler ultrasonography. Patients received daily sildenafil 50 mg for 3 months.
Thirty-one patients were followed up: 54.8% showed response to sildenafil defined as reporting successful vaginal penetration and intercourse. Patients with neurogenic, arterial, and venous EDs did not differ in efficiency rates (P = .587). However, the penile erectile rigidity recorded by NPTR test affected efficiency significantly (P = .046). Patients with tip rigidity >40% had the highest response rate (76.9%), but the response rate for patients with tip rigidity <20% was only 22.2%.
NPTR recording can reveal resident erectile function in patients with ED due to trauma and is significant for selecting pharmacologic treatment as optimal therapy.
评估骨盆骨折致尿道断裂所致勃起功能障碍（ED）患者的夜间阴茎勃起试验结果及每日服用西地那非的反应。
2010年1月至2012年1月，我们纳入了38例因骨盆骨折致尿道断裂而患有ED的患者。平均年龄为33.1岁（范围22 - 49岁）。所有患者均通过国际勃起功能指数-5、夜间阴茎肿胀和硬度（NPTR）试验以及阴茎多普勒超声进行主观和客观评估。患者每日服用50 mg西地那非，持续3个月。
31例患者得到随访：54.8%的患者对西地那非有反应，定义为报告成功的阴道插入和性交。神经源性、动脉性和静脉性ED患者的有效率无差异（P = 0.587）。然而，NPTR试验记录的阴茎勃起硬度对有效率有显著影响（P = 0.046）。尖端硬度>40%的患者反应率最高（76.9%），但尖端硬度<20%的患者反应率仅为22.2%。
NPTR记录可揭示创伤性ED患者的残余勃起功能，对选择药物治疗作为最佳治疗方法具有重要意义。
