Ma Ying, Duan Wei
Oncology Department, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, 251, Yaojiayuan Street, Chaoyang District, Beijing 100026, China.
World J Surg Oncol. 2014 Oct 12;12:311. doi: 10.1186/1477-7819-12-311.
Primary fallopian tube carcinoma (PFTC) is rarely seen clinically. Herein, we investigate the clinical and pathological characteristics and appropriate therapies for PFTC.
A total of 36 patients for whom PFTC was pathologically confirmed from January 2001 to July 2011 in Beijing Hospital of Gynecology and Obstetrics, an affiliate of Capital Medical University, were retrospectively analyzed.
A total of 36 cases underwent surgical staging in our hospital: 47.2% were early stage cases , and 52.8% were advanced stage cases. Of the 36 cases, 24 cases were pure adenocarcinoma, 10 cases were mixed, and there was 1 case of undifferentiated carcinoma, 1 case of undifferentiated carcinoma combined with transitional cell carcinoma, 5 cases of moderately differentiated carcinoma, and 29 cases of moderately to poorly differentiated carcinoma. There were no cases of highly differentiated carcinoma. Among the cases examined, 38.9% (14/36) had omentum metastasis, and 19 cases had an elevated CA125 during a preoperative biochemical laboratory test. Approximately 35 cases received postoperative adjuvant chemotherapy. The 3-year and 5-year overall survival rates for the 36 cases were 80.7% and 65.4%, respectively. Single-factor analysis showed that the pathological conditions of residual tumor diameter >1 cm (P < 0.001), omentum metastasis (P = 0.003), ovary metastasis (P = 0.004) and elevated preoperative CA125 (P = 0.044) were associated with prognosis, whereas pathological surgical staging (P = 0.069), retroperitoneal lymph node metastasis (P = 0.499), and pathological classification (P = 0.183) were not associated with prognosis. Multifactor analysis showed that a residual tumor diameter >1 cm (P = 0.019) and omentum metastasis (P = 0.015) were associated with prognosis, and were, therefore, the independent risk factors of prognosis.
PFTC is a rare female genital tract malignancy. Most patients are in an advanced stage at diagnosis, which results in a poor prognosis. Complete surgical staging and maximal resection should be recommended.
原发性输卵管癌（PFTC）在临床上较为少见。在此，我们对PFTC的临床和病理特征以及合适的治疗方法进行研究。
回顾性分析2001年1月至2011年7月在首都医科大学附属北京妇产医院经病理确诊为PFTC的36例患者。
我院共有36例患者接受了手术分期：47.2%为早期病例，52.8%为晚期病例。36例中，24例为纯腺癌，10例为混合型，1例为未分化癌，1例为未分化癌合并移行细胞癌，5例为中分化癌，29例为中至低分化癌。无高分化癌病例。在检查的病例中，38.9%（14/36）有大网膜转移，19例术前生化实验室检查时CA125升高。约35例患者接受了术后辅助化疗。36例患者的3年和5年总生存率分别为80.7%和65.4%。单因素分析显示，残留肿瘤直径>1 cm（P<0.001）、大网膜转移（P = 0.003）、卵巢转移（P = 0.004）和术前CA125升高（P = 0.044）与预后相关，而病理手术分期（P = 0.069）、腹膜后淋巴结转移（P = 0.499）和病理分类（P = 0.183）与预后无关。多因素分析显示，残留肿瘤直径>1 cm（P = 0.019）和大网膜转移（P = 0.015）与预后相关，因此是预后的独立危险因素。
PFTC是一种罕见的女性生殖道恶性肿瘤。大多数患者在诊断时处于晚期，预后较差。建议进行完整的手术分期和最大限度的切除。
