丙泊酚或阿法沙龙用于猫麻醉诱导和维持对呼吸影响的比较。
Comparison of the effects of propofol or alfaxalone for anaesthesia induction and maintenance on respiration in cats.
作者信息
Campagna Ivo, Schwarz Andrea, Keller Stefanie, Bettschart-Wolfensberger Regula, Mosing Martina
机构信息
Division of Anaesthesiology, Equine Department, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Section of Small Animal Reproduction, Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
出版信息
Vet Anaesth Analg. 2015 Sep;42(5):484-92. doi: 10.1111/vaa.12231. Epub 2014 Oct 13.
OBJECTIVE
To compare the effects of propofol and alfaxalone on respiration in cats.
STUDY DESIGN
Randomized, 'blinded', prospective clinical trial.
ANIMALS
Twenty cats undergoing ovariohysterectomy.
METHODS
After premedication with medetomidine 0.01 mg kg(-1) intramuscularly and meloxicam 0.3 mg kg(-1) subcutaneously, the cats were assigned randomly into two groups: group A (n = 10) were administered alfaxalone 5 mg kg(-1) minute(-1) followed by 10 mg kg(-1) hour(-1) intravenously (IV) and group P (n = 10) were administered propofol 6 mg kg(-1 ) minute(-1) followed by 12 mg kg(-1) hour(-1) IV for induction and maintenance of anaesthesia, respectively. After endotracheal intubation, the tube was connected to a non-rebreathing system delivering 100% oxygen. The anaesthetic maintenance drug rate was adjusted (± 0.5 mg kg(-1) hour(-1) ) every 5 minutes according to a scoring sheet based on physiologic variables and clinical signs. If apnoea > 30 seconds, end-tidal carbon dioxide (Pe'CO2 ) > 7.3 kPa (55 mmHg) or arterial haemoglobin oxygen saturation (SpO2 ) < 90% occurred, manual ventilation was provided. Methadone was administered postoperatively. Data were analyzed using independent-samples t-tests, Fisher's exact test, linear mixed-effects models and binomial test.
RESULTS
Manual ventilation was required in two and eight of the cats in group A and P, respectively (p = 0.02). Two cats in both groups showed apnoea. Pe'CO2 > 7.3 kPa was recorded in zero versus four and SpO2 < 90% in zero versus six cats in groups A and P respectively. Induction and maintenance dose rates (mean ± SD) were 11.6 ± 0.3 mg kg(-1) and 10.7 ± 0.8 mg kg(-1) hour(-1) for alfaxalone and 11.7 ± 2.7 mg kg(-1) and 12.4 ± 0.5 mg kg(-1) hour(-1) for propofol.
CONCLUSION AND CLINICAL RELEVANCE
Alfaxalone had less adverse influence on respiration than propofol in cats premedicated with medetomidine. Alfaxalone might be better than propofol for induction and maintenance of anaesthesia when artificial ventilation cannot be provided.
目的
比较丙泊酚和阿法沙龙对猫呼吸的影响。
研究设计
随机、“盲法”、前瞻性临床试验。
动物
20只接受卵巢子宫切除术的猫。
方法
猫肌肉注射0.01 mg kg⁻¹美托咪定和皮下注射0.3 mg kg⁻¹美洛昔康进行预处理后，随机分为两组：A组（n = 10）静脉注射阿法沙龙，先以5 mg kg⁻¹ min⁻¹的速度注射，随后以10 mg kg⁻¹ h⁻¹的速度注射；P组（n = 10）静脉注射丙泊酚，先以6 mg kg⁻¹ min⁻¹的速度注射，随后以12 mg kg⁻¹ h⁻¹的速度注射，分别用于诱导和维持麻醉。气管插管后，将气管导管连接至输送100%氧气的非再呼吸系统。根据基于生理变量和临床体征的评分表，每5分钟调整一次麻醉维持药物速率（±0.5 mg kg⁻¹ h⁻¹）。若出现呼吸暂停>30秒、呼气末二氧化碳（PetCO₂）>7.3 kPa（55 mmHg）或动脉血红蛋白氧饱和度（SpO₂）<90%，则进行人工通气。术后给予美沙酮。采用独立样本t检验、Fisher精确检验、线性混合效应模型和二项式检验对数据进行分析。
结果
A组和P组分别有2只和8只猫需要人工通气（p = 0.02）。两组均有2只猫出现呼吸暂停。A组和P组分别有0只和4只猫的PetCO₂>7.3 kPa，0只和6只猫的SpO₂<90%。阿法沙龙的诱导和维持剂量率（均值±标准差）分别为11.6±0.3 mg kg⁻¹和10.7±0.8 mg kg⁻¹ h⁻¹，丙泊酚分别为11.7±2.7 mg kg⁻¹和12.4±0.5 mg kg⁻¹ h⁻¹。
结论及临床意义
在接受美托咪定预处理的猫中，阿法沙龙对呼吸的不良影响小于丙泊酚。在无法提供人工通气的情况下，阿法沙龙在诱导和维持麻醉方面可能优于丙泊酚。
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