Arcaniolo Davide, Favilla Vincenzo, Tiscione Daniele, Pisano Francesca, Bozzini Giorgio, Creta Massimiliano, Gentile Giorgio, Menchini Fabris Filippo, Pavan Nicola, Veneziano Italo Antonio, Cai Tommaso
Department of Urology, University of Federico II, Naples.
Arch Ital Urol Androl. 2014 Sep 30;86(3):164-70. doi: 10.4081/aiua.2014.3.164.
Infertility affects 15% of couples in fertile age. Male factor is a cause of infertility in almost half of cases, mainly due to oligoasthenoteratozoospermia (OAT). The purpose of this study is to review the effects of nutritional supplements as medical treatment for idiopathic male infertility.
A Pub Med and Medline review of the published studies utilizing nutritional supplements for the treatment of male infertility has been performed.
Clinical trials on Vitamin E, Vitamin A, Vitamin C. Arginine, Carnitine, N-Acetyl-Carnitine, Glutathione, Coenzyme Q10, Selenium and Zinc were reviewed. Although there is a wide variability in selected population, dose regimen and final outcomes, nutritional supplements both alone and in combination seems to be able to improve semen parameters (sperm count, sperm motility and morphology) and pregnancy rate in infertile men.
There are rising evidences from published randomized trials and systematic review suggesting that nutritional supplementation may improve semen parameters and the likelihood of pregnancy in men affected by OAT. This improvement, however, is not consistent and there is a wide variation in the treatment regimens used. Well designed and adequately powered RCTs are needed to better clarify the role of nutritional supplements as treatment for male infertility.
不孕症影响15%的育龄夫妇。男性因素是近半数不孕症病例的病因，主要是由于少弱畸精子症（OAT）。本研究的目的是综述营养补充剂作为特发性男性不孕症医学治疗方法的效果。
对利用营养补充剂治疗男性不孕症的已发表研究进行了PubMed和Medline综述。
对维生素E、维生素A、维生素C、精氨酸、肉碱、N-乙酰肉碱、谷胱甘肽、辅酶Q10、硒和锌的临床试验进行了综述。尽管所选人群、剂量方案和最终结果存在很大差异，但营养补充剂单独使用或联合使用似乎都能够改善不育男性的精液参数（精子数量、精子活力和形态）以及妊娠率。
已发表的随机试验和系统评价中有越来越多的证据表明，营养补充可能改善受OAT影响男性的精液参数和妊娠可能性。然而，这种改善并不一致，且所用治疗方案存在很大差异。需要设计良好且有足够效力的随机对照试验来更好地阐明营养补充剂作为男性不孕症治疗方法的作用。
