Bahmyari Rezvan, Ariafar Ali, Sayadi Mehrab, Hossieni Shirzad, Azima Sara
Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Fertil Steril. 2021 Jan;15(1):8-14. doi: 10.22074/ijfs.2021.6236. Epub 2021 Jan 19.
Male infertility may originate from a wide spectrum of conditions while in 30-40 percent of cases, no significant reason can be identified. Thereby, it is recognized as male idiopathic infertility. This study was undertaken to investigate the effect of daily intake of selenium, vitamin E and folic acid on sperm parameters in males with idiopathic infertility.
Seventy infertile men were selected to participate in this single-blind, randomized controlled clinical trial using convenience sampling. They were equally divided into two groups via permuted block randomization method. The intervention group received selenium tablet (200 μg per day, oral), vitamin E capsule (400 IU per day, oral) and folic acid tablet (5 mg per day, oral).The placebo group received matching placebo for three months. Semen volume, total sperm motility, sperm concentration, progressive sperm motility, normal sperm morphology, sperm motility index (SMI) and functional sperm concentration (FSC) were assessed by sperm quality analyzer-v (SQAV) before and after the intervention. Paired t test, and independent t test were used to compare the results within and between the groups, respectively. The IBM SPSS V.16.005 was used for data analysis. A P<0.05 was considered statistically significant.
After three months, according to within-group analysis, a significant difference was found in mean SMI (P=0.007) and FSC (P=0.001) in the intervention group. According to between-group analysis, no significant difference was found in mean semen volume (P=0.610), sperm concentration (P=0.126), total sperm motility (P=0.765), progressive sperm motility (P=0.767), normal sperm morph (P=0.403), SMI (P=0.556) or FSC (P=0.706) between the groups.
Consumption of selenium, vitamin E and folic acid in infertile men with asthenozoospermia was not effective (Registration number: IRCT2017012432153N1).
男性不育可能由多种情况引起，而在30%至40%的病例中，无法确定明显原因。因此，这被认定为男性特发性不育。本研究旨在探讨每日摄入硒、维生素E和叶酸对特发性不育男性精子参数的影响。
采用便利抽样法选取70名不育男性参与这项单盲、随机对照临床试验。通过置换区组随机化方法将他们平均分为两组。干预组每日口服硒片（200微克）、维生素E胶囊（400国际单位）和叶酸片（5毫克）。安慰剂组服用匹配的安慰剂，为期三个月。干预前后使用精子质量分析仪 - v（SQAV）评估精液量、总精子活力、精子浓度、前向运动精子活力、正常精子形态、精子活力指数（SMI）和功能性精子浓度（FSC）。分别使用配对t检验和独立t检验比较组内和组间结果。使用IBM SPSS V.16.005进行数据分析。P<0.05被认为具有统计学意义。
三个月后，根据组内分析，干预组的平均SMI（P = 0.007）和FSC（P = 0.001）有显著差异。根据组间分析，两组之间的平均精液量（P = 0.610）、精子浓度（P = 0.126）、总精子活力（P = 0.765）、前向运动精子活力（P = 0.767）、正常精子形态（P = 0.403）、SMI（P = 0.556）或FSC（P = 0.706）无显著差异。
对于弱精子症的不育男性，摄入硒、维生素E和叶酸无效（注册号：IRCT2017012432153N1）。
