铜催化未活化的烷基甲苯磺酸酯和甲磺酸酯与烷基和芳基溴的还原交叉偶联反应。
Copper-catalyzed reductive cross-coupling of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides.
作者信息
Liu Jing-Hui, Yang Chu-Ting, Lu Xiao-Yu, Zhang Zhen-Qi, Xu Ling, Cui Mian, Lu Xi, Xiao Bin, Fu Yao, Liu Lei
机构信息
Department of Chemistry, University of Science and Technology of China, Hefei 230026 (P. R. China); State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000 Lanzhou (P. R. China); Department of Chemistry, Tsinghua University, Beijing 100084 (P. R. China).
出版信息
Chemistry. 2014 Nov 17;20(47):15334-8. doi: 10.1002/chem.201405223. Epub 2014 Oct 13.
A copper-catalyzed reductive cross-coupling reaction of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides was developed. It provides a practical method for efficient and cost-effective construction of aryl-alkyl and alkyl-alkyl CC bonds with stereocontrol from readily available substrates. When used in an intramolecular fashion, the reaction enables convenient access to various substituted carbo- or heterocycles, such as 2,3-dihydrobenzofuran and benzochromene derivatives.
开发了一种铜催化的未活化甲苯磺酸酯和甲磺酸酯与烷基和芳基溴的还原交叉偶联反应。它提供了一种实用的方法，可从容易获得的底物高效且经济地构建具有立体控制的芳基 - 烷基和烷基 - 烷基CC键。当以分子内方式使用时，该反应能够方便地获得各种取代的碳环或杂环，例如2,3 - 二氢苯并呋喃和苯并色烯衍生物。
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