Herszényi László, Barabás Loránd, Hritz István, István Gábor, Tulassay Zsolt
László Herszényi, Zsolt Tulassay, 2 Department of Medicine, Semmelweis University, H-1088 Budapest, Hungary.
World J Gastroenterol. 2014 Oct 7;20(37):13246-57. doi: 10.3748/wjg.v20.i37.13246.
Tumor invasion and metastasis is a highly complicated, multi-step phenomenon. In the complex event of tumor progression, tumor cells interact with basement membrane and extracellular matrix components. Proteolytic enzymes (proteinases) are involved in the degradation of extracellular matrix, but also in cancer invasion and metastasis. The four categories of proteinases (cysteine-, serine-, aspartic-, and metalloproteinases) are named and classified according to the essential catalytic component in their active site. We and others have shown that proteolytic enzymes play a major role not only in colorectal cancer (CRC) invasion and metastasis, but also in malignant transformation of precancerous lesions into cancer. Tissue and serum-plasma antigen concentrations of proteinases might be of great value in identifying patients with poor prognosis in CRC. Our results, in concordance with others indicate the potential tumor marker impact of proteinases for the early diagnosis of CRC. In addition, proteinases may also serve as potential target molecules for therapeutic agents.
肿瘤侵袭和转移是一个高度复杂的多步骤现象。在肿瘤进展这一复杂过程中，肿瘤细胞与基底膜及细胞外基质成分相互作用。蛋白水解酶（蛋白酶）不仅参与细胞外基质的降解，还与癌症侵袭和转移有关。这四类蛋白酶（半胱氨酸蛋白酶、丝氨酸蛋白酶、天冬氨酸蛋白酶和金属蛋白酶）是根据其活性位点中的关键催化成分来命名和分类的。我们和其他人已经表明，蛋白水解酶不仅在结直肠癌（CRC）的侵袭和转移中起主要作用，而且在癌前病变向癌症的恶性转化中也起主要作用。蛋白酶的组织和血清 - 血浆抗原浓度在识别CRC预后不良的患者中可能具有重要价值。我们的结果与其他人的结果一致，表明蛋白酶对CRC早期诊断具有潜在的肿瘤标志物影响。此外，蛋白酶还可能作为治疗药物的潜在靶分子。
