Tiwari Vishvanath, Tiwari Monalisa
Department of Biochemistry, Central University of Rajasthan Ajmer, India.
Front Microbiol. 2014 Sep 26;5:512. doi: 10.3389/fmicb.2014.00512. eCollection 2014.
Acinetobacter baumannii is an opportunistic pathogen causing pneumonia, respiratory infections and urinary tract infections. The prevalence of this lethal pathogen increases gradually in the clinical setup where it can grow on artificial surfaces, utilize ethanol as a carbon source. Moreover it resists desiccation. Carbapenems, a β-lactam, are the most commonly prescribed drugs against A. baumannii. Resistance against carbapenem has emerged in Acinetobacter baumannii which can create significant health problems and is responsible for high morbidity and mortality. With the development of quantitative proteomics, a considerable progress has been made in the study of carbapenem resistance of Acinetobacter baumannii. Recent updates showed that quantitative proteomics has now emerged as an important tool to understand the carbapenem resistance mechanism in Acinetobacter baumannii. Present review also highlights the complementary nature of different quantitative proteomic methods used to study carbapenem resistance and suggests to combine multiple proteomic methods for understanding the response to antibiotics by Acinetobacter baumannii.
鲍曼不动杆菌是一种引起肺炎、呼吸道感染和尿路感染的机会致病菌。这种致命病原体在临床环境中的患病率逐渐上升，它可以在人工表面生长，利用乙醇作为碳源。此外，它还能抵抗干燥。碳青霉烯类药物作为一种β-内酰胺类药物，是治疗鲍曼不动杆菌最常用的药物。鲍曼不动杆菌对碳青霉烯类药物的耐药性已经出现，这可能会造成严重的健康问题，并导致高发病率和死亡率。随着定量蛋白质组学的发展，鲍曼不动杆菌对碳青霉烯类药物耐药性的研究取得了相当大的进展。最近的进展表明，定量蛋白质组学现已成为了解鲍曼不动杆菌碳青霉烯类药物耐药机制的重要工具。本综述还强调了用于研究碳青霉烯类药物耐药性的不同定量蛋白质组学方法的互补性，并建议结合多种蛋白质组学方法来了解鲍曼不动杆菌对抗生素的反应。
