Khodadadi Ehsaneh, Zeinalzadeh Elham, Taghizadeh Sepehr, Mehramouz Bahareh, Kamounah Fadhil S, Khodadadi Ehsan, Ganbarov Khudaverdi, Yousefi Bahman, Bastami Milad, Kafil Hossein Samadi
Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Infect Drug Resist. 2020 Jun 16;13:1785-1806. doi: 10.2147/IDR.S238446. eCollection 2020.
Sequences of the genomes of all-important bacterial pathogens of man, plants, and animals have been completed. Still, it is not enough to achieve complete information of all the mechanisms controlling the biological processes of an organism. Along with all advances in different proteomics technologies, proteomics has completed our knowledge of biological processes all around the world. Proteomics is a valuable technique to explain the complement of proteins in any organism. One of the fields that has been notably benefited from other systems approaches is bacterial pathogenesis. An emerging field is to use proteomics to examine the infectious agents in terms of, among many, the response the host and pathogen to the infection process, which leads to a deeper knowledge of the mechanisms of bacterial virulence. This trend also enables us to identify quantitative measurements for proteins extracted from microorganisms. The present review study is an attempt to summarize a variety of different proteomic techniques and advances. The significant applications in bacterial pathogenesis studies are also covered. Moreover, the areas where proteomics may lead the future studies are introduced.
人类、植物和动物所有重要细菌病原体的基因组序列已全部完成。然而，要全面了解控制生物体生物过程的所有机制，这还远远不够。随着不同蛋白质组学技术的不断进步，蛋白质组学完善了我们对全球生物过程的认识。蛋白质组学是解释任何生物体中蛋白质组成的一项重要技术。细菌致病机制这一领域尤其受益于其他系统方法。一个新兴领域是利用蛋白质组学从诸多方面研究感染因子，包括宿主和病原体对感染过程的反应，从而更深入地了解细菌毒力机制。这一趋势还使我们能够对从微生物中提取的蛋白质进行定量测量。本综述旨在总结各种不同的蛋白质组学技术及其进展。同时还涵盖了其在细菌致病机制研究中的重要应用。此外，还介绍了蛋白质组学可能引领未来研究的领域。
