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Dechloro teicoplanin antibiotics.

作者信息

Malabarba A, Spreafico F, Ferrari P, Kettenring J, Strazzolini P, Tarzia G, Pallanza R, Berti M, Cavalleri B

机构信息

Merrell Dow Research Institute, Lepetit Research Center, Gerenzano, Italy.

出版信息

J Antibiot (Tokyo). 1989 Nov;42(11):1684-97. doi: 10.7164/antibiotics.42.1684.

DOI:10.7164/antibiotics.42.1684
PMID:2531135
Abstract

Mono- and didechlorinated derivatives of the antibiotic teicoplanin, its pseudoaglycones and aglycone, and of one amide and ester of deglucoteicoplanin were prepared under selective reductive conditions. The selectivity and rate of dehalogenation were studied and compared to those of vancomycin and deglucovancomycin. The influence of the chlorine substituents on the mechanism of action and antibacterial activity of teicoplanin antibiotics was also investigated.

摘要

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