Rabiei Zahra, Rafieian-Kopaei Mahmoud
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Asian Pac J Trop Med. 2014 Sep;7S1:S421-6. doi: 10.1016/S1995-7645(14)60269-8.
To evaluate the protective effect of Lavandula officinalis (L. officinalis) extract against blood-brain barrier (BBB) permeability and its possible mechanisms in an experimental model of stroke.
Focal cerebral ischemia was induced by the transient occlusion of the middle cerebral artery for 1 h in rats. Lavender extract (100, 200 mg/kg i.p.) was injected for 20 consecutive days. BBB permeability and oxidative stress biomarkers were evaluated using standard methods.
The results of this study showed that L. officinalis ethanolic extract significantly reduced the BBB permeability in experimental groups when compared with ischemia group. The lavender extract significantly reduced malondialdehyde levels of plasma and brain tissue in intact group when compared with control group.
L. officinalis extract reduced blood brain barrier permeability and alleviated neurological function in rats, and the mechanism may be related to augmentation in endogenous antioxidant defense and inhibition of oxidative stress in the rat brain.
在中风实验模型中评估薰衣草提取物对血脑屏障（BBB）通透性的保护作用及其可能机制。
通过大鼠大脑中动脉短暂闭塞1小时诱导局灶性脑缺血。连续20天腹腔注射薰衣草提取物（100、200毫克/千克）。使用标准方法评估血脑屏障通透性和氧化应激生物标志物。
本研究结果表明，与缺血组相比，薰衣草乙醇提取物显著降低了实验组的血脑屏障通透性。与对照组相比，薰衣草提取物显著降低了完整组血浆和脑组织的丙二醛水平。
薰衣草提取物降低了大鼠血脑屏障通透性并改善了神经功能，其机制可能与增强内源性抗氧化防御和抑制大鼠脑内氧化应激有关。
