Liu Bolong, Su Minzhi, Zhan Hailun, Yang Fei, Li Wenbiao, Zhou Xiangfu
Department of Urology, The Third Affiliated Hospital of the Sun Yat-Sen University, Guangzhou, China.
Department of Rehabilitation Medicine, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, Guangzhou, China.
Urology. 2014 Dec;84(6):1308-13. doi: 10.1016/j.urology.2014.08.018. Epub 2014 Oct 12.
To examine whether adding a sexual dysfunction domain to urinary, psychosocial, organ specific, infection, neurologic or systemic, and tenderness (UPOINT) system improves the association with interstitial cystitis and bladder pain syndrome (IC-BPS) symptom severity due to a high prevalence of sexual dysfunction in women.
A total of 90 Chinese women with IC-BPS were prospectively collected and classified in each domain of the UPOINT system. Symptom severity was measured using the Interstitial Cystitis Symptom Index (ICSI). The sexual function was evaluated using the Female Sexual Function Index (FSFI). Clinically relevant associations were calculated.
The percentage of patients positive for each domain were 90 of 90 (100%), 33 of 90 (37%), 88 of 90 (98%), 21 of 90 (23%), 36 of 90 (40%), 38 of 90 (42%), 62 of 90 (69%) for the urinary, psychosocial, organ specific, infection, neurologic or systemic, tenderness, and sexual dysfunction, respectively. There were significant associations between the number of domains and ICSI (Spearman r = 0.386; P <.05) and FSFI (Spearman r = 0.614; P <.001) scores. After adding a sexual dysfunction domain to create a modified UPOINTS system, the association between the number of domains and symptom severity was improved (correlation coefficient r changed from 0.386 to 0.572; P <.001). The presence of sexual dysfunction had a significant impact on the ICSI scores (P = .032), pain scores (P = .042), and quality of life index scores (P = .035). Significantly reduced FSFI scores were found in patients who had positive psychosocial, organ specific, and tenderness domains (all P values <.05).
Our study demonstrated sexual dysfunction was an important component of IC-BPS phenotype, and adding a sexual dysfunction domain to the UPOINT system improved the association with IC-BPS symptom severity.
鉴于女性性功能障碍的高患病率，研究在泌尿、心理社会、器官特异性、感染、神经或全身以及压痛（UPOINT）系统中增加性功能障碍领域是否能改善与间质性膀胱炎和膀胱疼痛综合征（IC - BPS）症状严重程度的相关性。
前瞻性收集90例患有IC - BPS的中国女性，并根据UPOINT系统的每个领域进行分类。使用间质性膀胱炎症状指数（ICSI）测量症状严重程度。使用女性性功能指数（FSFI）评估性功能。计算临床相关的相关性。
泌尿、心理社会、器官特异性、感染、神经或全身、压痛和性功能障碍领域阳性患者的百分比分别为90/90（100%）、33/90（37%）、88/90（98%）、21/90（23%）、36/90（40%）、38/90（42%）、62/90（69%）。领域数量与ICSI（Spearman相关系数r = 0.386；P <.05）和FSFI（Spearman相关系数r = 0.614；P <.001）评分之间存在显著相关性。在增加性功能障碍领域以创建改良的UPOINTS系统后，领域数量与症状严重程度之间的相关性得到改善（相关系数r从0.386变为0.572；P <.001）。性功能障碍的存在对ICSI评分（P =.032）、疼痛评分（P =.042）和生活质量指数评分（P =.035）有显著影响。在心理社会、器官特异性和压痛领域呈阳性的患者中发现FSFI评分显著降低（所有P值<.05）。
我们的研究表明性功能障碍是IC - BPS表型的重要组成部分，在UPOINT系统中增加性功能障碍领域可改善与IC - BPS症状严重程度的相关性。
