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嗜酸性膀胱炎:三例病例及十年回顾

Eosinophilic cystitis: three cases, and a review over 10 years.

作者信息

Mosholt Karina Sif Søndergaard, Dahl Claus, Azawi Nessn Htum

机构信息

Urological Department, Roskilde Hospital, Roskilde, Denmark.

出版信息

BMJ Case Rep. 2014 Oct 13;2014:bcr2014205708. doi: 10.1136/bcr-2014-205708.

Abstract

Eosinophilic cystitis (EC) is a rare disease. We describe three cases, where presentations of the disease are similar. To highlight probable causes of the disease, symptoms, clinical findings and treatment modalities, we reviewed 56 cases over a 10-year period. The most common symptoms were frequency, dysuria, urgency, pain and haematuria. Common clinical findings were presence of bladder mass, peripheral eosinophilia and thickened bladder wall. A variety of medical treatments were used, most frequently steroids, antibiotics and antihistamines. Recurrence occurred in patients on tapering or discontinuing prednisone, among other reasons. There is no consensus about the treatment of EC, but In light of our findings in this review, the treatment of choice in our department will be tapered prednisone over 6-8 weeks in combination with antihistamine.

摘要

嗜酸性膀胱炎(EC)是一种罕见疾病。我们描述了三例该疾病表现相似的病例。为突出该疾病可能的病因、症状、临床发现及治疗方式,我们回顾了10年间的56例病例。最常见的症状是尿频、尿痛、尿急、疼痛和血尿。常见的临床发现是膀胱肿块、外周血嗜酸性粒细胞增多和膀胱壁增厚。采用了多种药物治疗,最常用的是类固醇、抗生素和抗组胺药。除其他原因外,在逐渐减少或停用泼尼松的患者中出现了复发情况。关于嗜酸性膀胱炎的治疗尚无共识,但根据我们在本综述中的发现,我们科室的首选治疗方法将是在6 - 8周内逐渐减少泼尼松用量并联合使用抗组胺药。

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