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本文引用的文献

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Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole.对八种念珠菌属对氟康唑、泊沙康唑和伏立康唑耐药性检测的流行病学截断值的多实验室研究。
Antimicrob Agents Chemother. 2014;58(4):2006-12. doi: 10.1128/AAC.02615-13. Epub 2014 Jan 13.
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In vitro activities of isavuconazole and comparator antifungal agents tested against a global collection of opportunistic yeasts and molds.体外研究伊曲康唑和其他抗真菌药物对全球机会性酵母菌和霉菌的活性。
J Clin Microbiol. 2013 Aug;51(8):2608-16. doi: 10.1128/JCM.00863-13. Epub 2013 Jun 5.
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Autochthonous and dormant Cryptococcus gattii infections in Europe.欧洲本土和休眠的新型隐球菌感染。
Emerg Infect Dis. 2012 Oct;18(10):1618-24. doi: 10.3201/eid1810.120068.
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Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole.新型隐球菌-格特隐球菌种复合体：氟康唑、伊曲康唑、泊沙康唑和伏立康唑野生型药敏终点分布和流行病学折点的国际研究。
Antimicrob Agents Chemother. 2012 Nov;56(11):5898-906. doi: 10.1128/AAC.01115-12. Epub 2012 Sep 4.
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Extensive genetic diversity within the Dutch clinical Cryptococcus neoformans population.荷兰临床新型隐球菌群体内广泛的遗传多样性。
J Clin Microbiol. 2012 Jun;50(6):1918-26. doi: 10.1128/JCM.06750-11. Epub 2012 Mar 21.
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Cryptococcus gattii in the United States: clinical aspects of infection with an emerging pathogen.美国的荚膜组织胞浆菌：一种新兴病原体感染的临床特征。
Clin Infect Dis. 2011 Dec;53(12):1188-95. doi: 10.1093/cid/cir723. Epub 2011 Oct 19.
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A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients.加利福尼亚南部 HIV/AIDS 患者中存在多种 VGIII 型荚膜组织胞浆菌。
PLoS Pathog. 2011 Sep;7(9):e1002205. doi: 10.1371/journal.ppat.1002205. Epub 2011 Sep 1.
8
In vitro antifungal susceptibility profiles and genotypes of 308 clinical and environmental isolates of Cryptococcus neoformans var. grubii and Cryptococcus gattii serotype B from north-western India.来自印度西北部的 308 株新型隐球菌和格特隐球菌 B 型临床和环境分离株的体外抗真菌药敏谱和基因型。
J Med Microbiol. 2011 Jul;60(Pt 7):961-967. doi: 10.1099/jmm.0.029025-0. Epub 2011 Mar 10.
9
In vitro antifungal susceptibilities and amplified fragment length polymorphism genotyping of a worldwide collection of 350 clinical, veterinary, and environmental Cryptococcus gattii isolates.对全球范围内 350 株临床、兽医和环境分离的隐球菌的体外抗真菌药敏试验和扩增片段长度多态性基因分型研究。
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10
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采用CLSI M27 - A3肉汤微量稀释法对新生隐球菌-格特隐球菌复合种的异氟康唑MIC分布及流行病学截断值进行多中心研究。

Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method.

作者信息

Espinel-Ingroff A, Chowdhary A, Gonzalez G M, Guinea J, Hagen F, Meis J F, Thompson G R, Turnidge J

机构信息

VCU Medical Center, Richmond, Virginia, USA

Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.

出版信息

Antimicrob Agents Chemother. 2015 Jan;59(1):666-8. doi: 10.1128/AAC.04055-14. Epub 2014 Oct 13.

DOI:10.1128/AAC.04055-14
PMID:25313209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4291414/
Abstract

Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 μg/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.

摘要

对于隐球菌属，目前尚无艾沙康唑的流行病学临界值（ECV）。基于来自六个实验室和不同地理区域的438株非基因分型新生隐球菌分离株、870株VNI基因型分离株以及406株加氏隐球菌分离株的野生型（WT）最低抑菌浓度（MIC）分布，艾沙康唑的ECV分别为0.06、0.12和0.25μg/ml。这些ECV可能有助于检测对艾沙康唑敏感性降低的非WT分离株。