Goldmacher Gregory V, Raunig David
ICON Medical Imaging, Warrington, Pennsylvania.
Neuro Oncol. 2014 Oct;16 Suppl 7(Suppl 7):vii48-50. doi: 10.1093/neuonc/nou225.
Multicenter clinical trials that include medical images as a key component of response assessment often involve an imaging service provider (a core laboratory or contract research organization) to collect images and often to provide independent assessments of treatment response. The brief discussion and recommendations provided here are not intended as a rigorous academic analysis but reflect the practical experience accumulated at one such institution, which has conducted the image collection and review for numerous glioblastoma trials, in every phase of drug development, encompassing over 4000 patients scanned at over 900 sites.
多中心临床试验将医学影像作为疗效评估的关键组成部分，通常会涉及一家影像服务提供商（核心实验室或合同研究组织）来收集影像，并常常提供独立的治疗反应评估。此处提供的简要讨论和建议并非严谨的学术分析，而是反映了一家这样的机构积累的实践经验。该机构在药物研发的各个阶段，为众多胶质母细胞瘤试验进行了影像收集和审查，涵盖了在900多个地点扫描的4000多名患者。
