Hall-Edwards Radiotherapy Research Group, Queen Elizabeth Hospital, Birmingham, UK.
Clin Oncol (R Coll Radiol). 2012 Apr;24(3):216-27. doi: 10.1016/j.clon.2011.06.004. Epub 2011 Jul 23.
Since postoperative radiotherapy plus concomitant temozolomide followed by adjuvant temozolomide has become standard treatment for glioblastoma, the phenomenon of early post-treatment enlargement of the imaged tumour volume, usually without clinical deterioration, has become widely recognised. The term pseudoprogression has been used to describe a poorly understood pathophysiological process. In this review, the pathophysiological concepts, relevance, diagnosis and management of patients with 'pseudoprogression' and 'pseudoresponse' are discussed. Guidelines are given with respect to radiological imaging modality, mode and frequency. Further biological and clinical insights into these phenomena require carefully designed prospective studies.
由于术后放疗联合替莫唑胺同期治疗后序贯替莫唑胺辅助治疗已成为胶质母细胞瘤的标准治疗方法，因此通常无临床恶化的影像学肿瘤体积治疗后早期增大的现象已被广泛认识。术语“假性进展”已被用于描述一种尚未完全了解的病理生理过程。在本综述中，讨论了“假性进展”和“假性缓解”患者的病理生理概念、相关性、诊断和处理。并提供了影像学检查方式、模式和频率的指南。需要精心设计前瞻性研究来进一步深入了解这些现象的生物学和临床特征。
