Yogarajah Meera, Sivasambu Bhradeev
Department of Medicine, Interfaith Medical Center, 1545 Atlantic Avenue, Brooklyn, NY 11213, USA.
Case Rep Rheumatol. 2014;2014:768321. doi: 10.1155/2014/768321. Epub 2014 Sep 17.
Kikuchi-Fujimoto disease is a rare benign condition of necrotising histiocytic lymphadenitis with unknown aetiology. We describe here a 30-year-old African American female who presented with fever, generalized rash, cervical lymphadenopathy, and oral candidiasis and was found to have Kikuchi-Fujimoto disease on lymph node biopsy with low CD4 count. The initial presentation was concerning for acute retroviral infection. Her HIV serology and HIV RNA PCR were negative however she had low CD4 count with reversal of CD4/CD8 ratio. Although low CD4 count has been associated with autoimmune disease, it has not been described with Kikuchi-Fujimoto disease. We report the first case of Kikuchi-Fujimoto disease associated with symptomatic CD4 lymphocytopenia.
菊池-藤本病是一种病因不明的罕见的坏死性组织细胞性淋巴结炎良性疾病。我们在此描述一名30岁的非裔美国女性，她出现发热、全身性皮疹、颈部淋巴结病和口腔念珠菌病，淋巴结活检发现患有菊池-藤本病，且CD4计数低。最初的表现令人担忧急性逆转录病毒感染。她的HIV血清学和HIV RNA PCR均为阴性，但她的CD4计数低，CD4/CD8比值倒置。虽然CD4计数低与自身免疫性疾病有关，但菊池-藤本病尚无相关描述。我们报告首例与有症状的CD4淋巴细胞减少相关的菊池-藤本病病例。
