Arshad Faheem, Bhat Tahir Saleem, Lone Abdul Rashid
Department of Internal Medicine, Sher-i-Kashmir Institute of Medical Sciences, Soura, Jammu and Kashmir, India.
J Cancer Res Ther. 2014 Jul-Sep;10(3):742-4. doi: 10.4103/0973-1482.136025.
Lyell's syndrome or toxic epidermal necrolysis (TEN) is a life threatening complication mostly caused by medications, characterized by desquamative lesions of the skin and mucous membranes with 30 percent or more epidermal involvement along with mucus membrane. We report a rare case of toxic epidermal necrolysis following administration of docetaxel, a semi-synthetic taxane. A female diagnosed as having metastatic breast carcinoma received chemotherapy in form of docetaxel after being exposed to adjuvant chemotherapy, developed severe involvement of skin and mucus membrane. Diagnosis of TEN was made and she was managed with steroids, antibiotics, intravenous fluids and antiseptic dressings. Common toxicities reported with this drug include myelosuppression, alopecia, nail damage, erythema multiforme major and neuropathy. We believe this is the first case report of Lyell's syndrome following docetaxel. Main aim of this case is to make physicians aware of the severe skin reactions with docetaxel, measures to avoid them, early recognition and prompt treatment.
莱尔综合征或中毒性表皮坏死松解症（TEN）是一种主要由药物引起的危及生命的并发症，其特征为皮肤和黏膜出现剥脱性病变，表皮受累达30%或更多，同时伴有黏膜病变。我们报告了一例使用多西他赛（一种半合成紫杉烷类药物）后发生中毒性表皮坏死松解症的罕见病例。一名被诊断为转移性乳腺癌的女性在接受辅助化疗后，以多西他赛进行化疗，随后出现严重的皮肤和黏膜受累。诊断为TEN后，对她采用了类固醇、抗生素、静脉输液和抗菌敷料进行治疗。该药物报告的常见毒性包括骨髓抑制、脱发、指甲损伤、重症多形红斑和神经病变。我们认为这是首例关于多西他赛后发生莱尔综合征的病例报告。本病例的主要目的是让医生了解多西他赛引起的严重皮肤反应、避免这些反应的措施、早期识别及及时治疗。
