Modi Yashpal, Shaaban Hamid, Gauchan Dron, Maroules Michael, Parikh Nalini, Guron Gunwant
Department of Pathology, Hematology and Oncology, St Michael's Medical Center, Newark, NJ, USA.
J Cancer Res Ther. 2014 Jul-Sep;10(3):773-6. doi: 10.4103/0973-1482.136043.
We present a very rare, interesting case of a carcinoma of the pancreas with predominantly abundant clear cell morphology. According to the WHO classification, primary clear cell carcinoma of the pancreas is classified as a rare "miscellaneous" carcinoma. The tumor was observed in the distal body and tail of the pancreas of a 74-year-old woman. The histopathology of tumor cells showed well-defined cell membranes, clear cytoplasm, and prominent cell boundaries. Immunohistochemical (IHC) staining showed positive reactions to antibodies against vimentin, cytokeratin 7 (CK-7), mucicarmine (MUC-1), periodic acid-Schiff (PAS), periodic acid-Schiff with diastase (PASD), carcinoembryonic antigen (CEA), and Carbohydrate Antigen 19-9 (CA 19-9). On the other hand, IHC staining was negative for alpha-fetoprotein (AFP), cytokeratin 20 (CK-20), HMB45, chromogranin, and synaptophysin. The patient was subsequently diagnosed with a primary solid-type pancreatic clear cell carcinoma with hepatic metastasis. Herein, we report this rare case and include a review of the current literature of this tumor.
我们报告了一例极为罕见且有趣的胰腺癌病例，其肿瘤细胞形态以丰富的透明细胞为主。根据世界卫生组织（WHO）分类，胰腺原发性透明细胞癌被归类为罕见的“其他”癌。该肿瘤在一名74岁女性的胰腺体尾部被发现。肿瘤细胞的组织病理学表现为细胞膜清晰、细胞质透明且细胞边界明显。免疫组织化学（IHC）染色显示，肿瘤细胞对波形蛋白、细胞角蛋白7（CK - 7）、黏液卡红（MUC - 1）、过碘酸希夫（PAS）、淀粉酶消化过碘酸希夫（PASD）、癌胚抗原（CEA）和糖类抗原19 - 9（CA 19 - 9）抗体呈阳性反应。另一方面，IHC染色对甲胎蛋白（AFP）、细胞角蛋白20（CK - 20）、HMB45、嗜铬粒蛋白和突触素呈阴性。该患者随后被诊断为原发性实性型胰腺透明细胞癌伴肝转移。在此我们报告这一罕见病例，并对该肿瘤的当前文献进行综述。
