Tomioka K, Yamada T, Mase T, Murase K
Department of Pharmacology, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Pharmacology. 1989;39(1):28-38. doi: 10.1159/000138568.
Effect of YM-11124 on cell-mediated immune responses, type I to type III allergic reactions and inflammatory reaction was determined in mice, rats and guinea pigs. YM-11124 inhibited picryl chloride- and methylated bovine serum albumin-induced delayed-type hypersensitivity reactions by the treatment during both the sensitization and the elicitation phases in mice. Bilateral adrenalectomy did not prevent the suppression of DTH response by YM-11124. YM-11124 significantly prolonged the survival time of allogenic skin grafts in mice. Furthermore, YM-11124 inhibited the passive Arthus reaction in guinea pigs and the reversed passive Arthus reaction in rats. However, YM-11124 did not affect the passive cutaneous anaphylaxis reaction in rats, Forssman shock in guinea pigs and paw edema in rats. These results indicate that YM-11124 suppresses not only cell-mediated immune responses (type IV allergic reactions) but also type III allergic reactions without influence on types I and II allergic reactions as well as acute inflammation.
在小鼠、大鼠和豚鼠中测定了YM - 11124对细胞介导的免疫反应、I型至III型过敏反应和炎症反应的影响。YM - 11124在小鼠致敏期和激发期进行治疗时，可抑制氯化苦基和甲基化牛血清白蛋白诱导的迟发型超敏反应。双侧肾上腺切除术并不能阻止YM - 11124对迟发型超敏反应的抑制作用。YM - 11124显著延长了小鼠同种异体皮肤移植的存活时间。此外，YM - 11124抑制豚鼠的被动Arthus反应和大鼠的反向被动Arthus反应。然而，YM - 11124不影响大鼠的被动皮肤过敏反应、豚鼠的福斯曼休克和大鼠的爪肿胀。这些结果表明，YM - 11124不仅抑制细胞介导的免疫反应（IV型过敏反应），还抑制III型过敏反应，而对I型和II型过敏反应以及急性炎症无影响。
