Department of Chemistry, Jinan University , Guangzhou 510632, China.
ACS Appl Mater Interfaces. 2014;6(21):19217-28. doi: 10.1021/am505246w. Epub 2014 Oct 29.
Radiotherapy displays curative potential for cervical cancer management, but radioresistance occurs during long-term therapy. To overcome this limitation, tumor-targeted nanotechnology has been proposed to enhance the radiosensitivity of solid tumors. Herein, we used biocompatible bovine serum albumin nanoparticles (BSANPs) as carriers of organic selenocompound (PSeD) with folate (FA) as the targeting ligand to fabricate a cancer-targeted nanosystem. The combination of PSeD and BSANPs endowed the nanosystem with higher light absorption and reactive oxygen species (ROS) generation owing to their properties of surface plasmon resonance (SPR) effect, heavy metal effect, high refractive index and nanoparticulate interfacial effect. The combined treatment drastically increased the ROS overproduction, VEGF/VEGFR2 inactivation and inhibition of XRCC-1-mediated repair of DNA damage, thus triggering G2/M phase arrest and apoptosis. Taken together, our findings demonstrate the utility of FA-BSANPs as a promising radiosensitizer to improve cancer radiotherapy.
放射疗法在宫颈癌的治疗中具有一定的疗效，但在长期治疗中会出现放射抵抗。为了克服这一局限性，肿瘤靶向纳米技术被提出以提高实体瘤的放射敏感性。在此，我们使用生物相容性牛血清白蛋白纳米颗粒（BSANPs）作为有机硒化合物（PSeD）的载体，以叶酸（FA）作为靶向配体，构建了一种癌症靶向纳米系统。PSeD 和 BSANPs 的结合由于其表面等离子体共振（SPR）效应、重金属效应、高折射率和纳米界面效应的特性，赋予了纳米系统更高的光吸收和活性氧（ROS）生成能力。联合治疗可显著增加 ROS 的过度产生，抑制 VEGF/VEGFR2 的失活以及 XRCC-1 介导的 DNA 损伤修复，从而触发 G2/M 期阻滞和细胞凋亡。综上所述，我们的研究结果表明，FA-BSANPs 作为一种有前途的放射增敏剂，可用于改善癌症的放射治疗。
