Song Xiaoyu, Sun Zhenkun, Li Li, Zhou Lu, Yuan Shuanghu
School of Clinical Medicine, Weifang Medical University, Weifang, China.
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Jinan, China.
Front Oncol. 2023 Feb 15;13:1088878. doi: 10.3389/fonc.2023.1088878. eCollection 2023.
Radiation therapy is an important component of cancer treatment. As research in radiotherapy techniques advances, new methods to enhance tumor response to radiation need to be on the agenda to enable enhanced radiation therapy at low radiation doses. With the rapid development of nanotechnology and nanomedicine, the use of nanomaterials as radiosensitizers to enhance radiation response and overcome radiation resistance has attracted great interest. The rapid development and application of emerging nanomaterials in the biomedical field offers good opportunities to improve the efficacy of radiotherapy, which helps to promote the development of radiation therapy and will be applied in clinical practice in the near future. In this paper, we discuss the main types of nano-radiosensitizers and explore their sensitization mechanisms at the tissue level, cellular level and even molecular biology and genetic level, and analyze the current status of promising nano-radiosensitizers and provide an outlook on their future development and applications.
放射治疗是癌症治疗的重要组成部分。随着放射治疗技术研究的进展，提高肿瘤对辐射反应的新方法需要提上日程，以便在低辐射剂量下实现增强的放射治疗。随着纳米技术和纳米医学的迅速发展，使用纳米材料作为放射增敏剂来增强辐射反应和克服辐射抗性已引起极大关注。新兴纳米材料在生物医学领域的快速发展和应用为提高放射治疗疗效提供了良好机遇，这有助于推动放射治疗的发展，并将在不久的将来应用于临床实践。在本文中，我们讨论了纳米放射增敏剂的主要类型，并在组织水平、细胞水平甚至分子生物学和基因水平上探索它们的增敏机制，分析了有前景的纳米放射增敏剂的现状，并对其未来的发展和应用进行了展望。
