Martinsson U, Sundström C, Glimelius B
Department of Oncology, University of Uppsala, Akademiska sjukhuset, Sweden.
APMIS. 1989 Nov;97(11):1025-32. doi: 10.1111/j.1699-0463.1989.tb00513.x.
The differential diagnosis between lymphocytic lymphoma of the B-CLL type and immunocytoma (IC) can be difficult when it is based only upon morphological criteria. With the aim of improving the distinction between these subgroups, frozen sections of lymph nodes or other biopsied tissues from 14 cases of B-CLL and 16 cases of IC were investigated according to immunophenotype. A panel of 13 B cell-associated and 2 T cell-associated monoclonal antibodies was used. All but one of the B-CLL cases were FMC7-, while 14/16 IC cases were FMC7+ (p less than 0.001). The two negative IC cases were both of the lymphoplasmacytic type, claimed to be "more differentiated" than the lymphoplasmacytoid type. We suggest that the cells in these cases are mature enough to have lost their FMC7 positivity, similar to plasma cells. There was also a statistically significant (p less than 0.01) difference, although not as pronounced, for the anti-CD38 antibody (Leu-17, B-CLL: 3/14, IC: 10/16 positive). No significant difference in expression of determinants was found for any of the other antibodies.
仅基于形态学标准来鉴别B细胞慢性淋巴细胞白血病（B-CLL）型淋巴细胞淋巴瘤和免疫细胞瘤（IC）可能存在困难。为了更好地区分这些亚组，根据免疫表型对14例B-CLL和16例IC患者的淋巴结或其他活检组织冰冻切片进行了研究。使用了一组13种B细胞相关单克隆抗体和2种T细胞相关单克隆抗体。除1例B-CLL病例外，其余均为FMC7阴性，而16例IC病例中有14例为FMC7阳性（p<0.001）。2例阴性IC病例均为淋巴浆细胞型，据称比淋巴浆细胞样型“分化程度更高”。我们认为这些病例中的细胞已足够成熟，以至于失去了FMC7阳性，类似于浆细胞。抗CD38抗体（Leu-17）也存在统计学显著差异（p<0.01），尽管差异不那么明显（B-CLL：3/14阳性，IC：10/16阳性）。对于其他任何抗体，未发现决定性表达有显著差异。
