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Differential effects of the stimulation of complement receptors CR1 (CD35) and CR2 (CD21) on cell proliferation and intracellular Ca2+ mobilization of chronic lymphocytic leukemia B cells.补体受体CR1（CD35）和CR2（CD21）刺激对慢性淋巴细胞白血病B细胞增殖和细胞内Ca2+动员的不同作用。
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IL-13 has only a subset of IL-4-like activities on B chronic lymphocytic leukaemia cells.白细胞介素-13对B慢性淋巴细胞白血病细胞仅具有一部分类似于白细胞介素-4的活性。
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A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL.CD21低表型，且无针对补体蛋白自身抗体的证据，这与慢性淋巴细胞白血病的不良预后一致。
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本文引用的文献

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Paraformaldehyde fixation of hematopoietic cells for quantitative flow cytometry (FACS) analysis.用于定量流式细胞术（FACS）分析的造血细胞多聚甲醛固定。
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A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis.一项基于多变量生存分析得出的慢性淋巴细胞白血病新预后分类。
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Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin.由单克隆抗体定义的人类T细胞抗原：T细胞的65000道尔顿抗原（T65）也存在于带有表面免疫球蛋白的慢性淋巴细胞白血病细胞上。
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Expression of human B cell-associated antigens on leukemias and lymphomas: a model of human B cell differentiation.人类B细胞相关抗原在白血病和淋巴瘤中的表达：一种人类B细胞分化模型
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Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1).鉴定一种对膜补体受体1（CR1）具有特异性的抗单核细胞单克隆抗体。
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Limiting dilution analysis of Epstein-Barr virus-induced immunoglobulin production by human B cells.爱泼斯坦-巴尔病毒诱导人B细胞产生免疫球蛋白的有限稀释分析。
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8
Monoclonal antibodies to Epstein-Barr virus-induced, transformation-associated cell surface antigens: binding patterns and effect upon virus-specific T-cell cytotoxicity.针对爱泼斯坦-巴尔病毒诱导的、转化相关细胞表面抗原的单克隆抗体：结合模式及其对病毒特异性T细胞细胞毒性的影响。
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Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody.人B细胞分化过程中C3d受体的表达：用HB-5单克隆抗体进行免疫荧光分析。
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10
Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes.鉴定一种145,000道尔顿的膜蛋白为人B淋巴细胞的C3d受体（CR2）。
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慢性淋巴细胞白血病肿瘤性B细胞上2型补体受体（CR2）表达降低。

Decreased expression of complement receptor type 2 (CR2) on neoplastic B cells of chronic lymphocytic leukaemia.

作者信息

Tooze J A, Bevan D H

机构信息

Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London, England.

出版信息

Clin Exp Immunol. 1991 Mar;83(3):423-9. doi: 10.1111/j.1365-2249.1991.tb05655.x.

DOI:10.1111/j.1365-2249.1991.tb05655.x
PMID:1825940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1535322/
Abstract

Neoplastic cells from 49 patients with B cell chronic lymphocytic leukaemia (B-CLL) were studied and compared with normal peripheral and tonsillar B cells using CD21 monoclonal antibodies. Membrane expression of CR2 was quantified by calibrated flow cytometry and by binding analysis with radiolabelled antibody. Both assays indicate that B-CLL cells express only 30% of the CR2 found on normal B cells. These findings are further evidence of the aberrant phenotype of B-CLL cells.

摘要

对49例B细胞慢性淋巴细胞白血病（B-CLL）患者的肿瘤细胞进行了研究，并使用CD21单克隆抗体与正常外周血和扁桃体B细胞进行比较。通过校准流式细胞术和用放射性标记抗体的结合分析对CR2的膜表达进行定量。两种检测均表明，B-CLL细胞仅表达正常B细胞上发现的CR2的30%。这些发现进一步证明了B-CLL细胞异常的表型。