Ausubel Frederick M
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 andDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114.
Genetics. 2014 Oct;198(2):431-4. doi: 10.1534/genetics.114.169102.
THE Genetics Society of America's Thomas Hunt Morgan Medal is awarded to an individual GSA member for lifetime achievement in the field of genetics. The 2014 recipient is Frederick Ausubel, whose 40-year career has centered on host-microbe interactions and host innate immunity. He is widely recognized as a key scientist responsible for establishing the modern postrecombinant DNA field of host-microbe interactions using simple nonvertebrate hosts. He has used genetic approaches to conduct pioneering work that spawned six related areas of research: the evolution and regulation of Rhizobium genes involved in symbiotic nitrogen fixation; the regulation of Rhizobium genes by two-component regulatory systems involving histidine kinases; the establishment of Arabidopsis thaliana as a worldwide model system; the identification of a large family of plant disease resistance genes; the identification of so-called multi-host bacterial pathogens; and the demonstration that Caenorhabditis elegans has an evolutionarily conserved innate immune system that shares features of both plant and mammalian immunity.
美国遗传学会的托马斯·亨特·摩根奖章授予在遗传学领域取得终身成就的美国遗传学会会员。2014年的获奖者是弗雷德里克·奥苏贝尔，他40年的职业生涯主要围绕宿主与微生物的相互作用以及宿主先天免疫展开。他被广泛认为是一位关键科学家，负责利用简单的非脊椎动物宿主建立宿主与微生物相互作用的现代重组DNA后领域。他运用遗传学方法开展了开创性工作，催生了六个相关研究领域：参与共生固氮的根瘤菌基因的进化与调控；涉及组氨酸激酶的双组分调控系统对根瘤菌基因的调控；拟南芥作为全球模型系统的建立；一大类植物抗病基因的鉴定；所谓多宿主细菌病原体的鉴定；以及证明秀丽隐杆线虫具有进化上保守的先天免疫系统，该系统兼具植物和哺乳动物免疫的特征。
