Central Virology Laboratory, Public Health Services, Israel Ministry of Health, Sheba Medical Center Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv.
Division of Epidemiology Public Health Services Braun School of Public Health and Community Medicine, Hebrew University Hadassah Faculty of Medicine, Jerusalem.
J Infect Dis. 2014 Nov 1;210 Suppl 1:S304-14. doi: 10.1093/infdis/jiu294.
Wild poliovirus type 1 (WPV1) introduction into southern Israel in early 2013 was detected by routine environmental surveillance. The virus was identified genetically as related to the South Asian (SOAS) R3A lineage endemic to Pakistan in 2012. Intensified, high-throughput environmental surveillance using advanced molecular methods played a critical role in documenting and locating sustained transmission throughout 2013 and early 2014 in the absence of any acute flaccid paralysis. It guided the public health responses, including stool-based surveillance and serosurveys, to determine the point prevalence in silent excretors and measured the effect of vaccination campaigns with inactivated polio vaccine and bivalent oral polio vaccine on stopping transmission.
2013 年初，在以色列南部发现了野生脊髓灰质炎病毒 1 型（WPV1），这是通过常规环境监测发现的。该病毒在基因上被确定为与巴基斯坦 2012 年流行的南亚（SOAS）R3A 谱系有关。在没有任何急性弛缓性麻痹的情况下，使用先进分子方法进行强化、高通量的环境监测在记录和定位 2013 年全年和 2014 年初持续传播方面发挥了关键作用。它指导了包括基于粪便的监测和血清学调查在内的公共卫生应对措施，以确定无症状排泄者的时点患病率，并衡量使用灭活脊髓灰质炎疫苗和二价口服脊髓灰质炎疫苗进行疫苗接种运动对阻止传播的效果。
