Samal Sunil K, Rathod Setu, Ghose Seetesh
Department of Obstetrics and Gynaecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.
J Midlife Health. 2014 Jul;5(3):159-61. doi: 10.4103/0976-7800.141229.
Choriocarcinoma is a highly malignant epithelial tumor originating from trophoblast. It primarily occurs during the fertile period. Postmenopausal uterine choriocarcinoma is very rare. We present a case of choriocarcinoma in a postmenopausal lady developing 5 years after menopause. She presented with heavy postmenopausal bleeding along with passage of vesicles per vaginum. Serum beta-hCG was 96,484 mIU/ml. Emergency abdominal hysterectomy with bilateral salpingo-ooperectomy was done due to intractable bleeding following suction and evacuation. Histopathology revealed uterine choriocarcinoma. She was treated with EMACO regimen following which her beta-hCG returned to normal in five cycles. The patient is under regular follow-up and is doing well.
绒毛膜癌是一种起源于滋养层的高度恶性上皮性肿瘤。它主要发生在育龄期。绝经后子宫绒毛膜癌非常罕见。我们报告一例绝经后女性在绝经5年后发生绒毛膜癌的病例。她表现为绝经后大量出血并伴有经阴道排出水泡状物。血清β-人绒毛膜促性腺激素为96484 mIU/ml。由于吸宫和刮宫后出血难以控制，遂行急诊腹式子宫切除术及双侧输卵管卵巢切除术。组织病理学检查显示为子宫绒毛膜癌。她接受了EMA-CO方案治疗，治疗五个周期后β-人绒毛膜促性腺激素恢复正常。患者正在定期随访，情况良好。
