补充镁、铁和锌治疗注意力缺陷多动障碍：近期文献的系统评价
Magnesium, Iron, and Zinc Supplementation for the Treatment of Attention Deficit Hyperactivity Disorder: A Systematic Review on the Recent Literature.
作者信息
Hariri Mitra, Azadbakht Leila
机构信息
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Int J Prev Med. 2015 Sep 2;6:83. doi: 10.4103/2008-7802.164313. eCollection 2015.
BACKGROUND
The etiology of attention deficit hyperactivity disorder (ADHD) is not exactly known and its etiology is multifactorial. The usual treatment for these children is based on pharmacotherapy treatment, although the pharmacotherapy has a high effectiveness in ADHD treatment, it often causes different side effects. Existing evidence suggests that children who receive mineral supplement without considering their age and supplement formula may perform better on different behavioral tests compared with those receiving placebo.
METHODS
In this study, we tried to review the previous evidence regarding the effects of minerals in prevention and management of ADHD. We searched PubMed/Medline, Google Scholar, Ovid, Scopus, and ISI web of science up to June 2013. "iron," "iron supplementation," "magnesium," "magnesium supplementation," "zinc," "zinc supplementation," "attention deficit hyperactivity disorder" were used as the keywords. Totally 11 randomized controlled trials were eligible to be included in the systematic review.
RESULTS
Our review showed that we don't have any predominant evidence about using mineral supplementation on children with ADHD.
CONCLUSIONS
We need more evidence for indicating the effect of zinc, magnesium, and iron supplementation in the treatment of ADHD among children.
背景
注意力缺陷多动障碍（ADHD）的病因尚不完全清楚，其病因是多因素的。这些儿童的常规治疗基于药物治疗，尽管药物治疗在ADHD治疗中具有很高的有效性，但它常常会引起不同的副作用。现有证据表明，与接受安慰剂的儿童相比，不考虑年龄和补充剂配方而接受矿物质补充剂的儿童在不同的行为测试中可能表现得更好。
方法
在本研究中，我们试图回顾先前关于矿物质在预防和管理ADHD方面作用的证据。我们检索了截至2013年6月的PubMed/Medline、谷歌学术、Ovid、Scopus和科学网ISI。使用“铁”“铁补充剂”“镁”“镁补充剂”“锌”“锌补充剂”“注意力缺陷多动障碍”作为关键词。共有11项随机对照试验符合纳入系统评价的条件。
结果
我们的综述表明，对于ADHD儿童使用矿物质补充剂，我们没有任何占主导地位的证据。
结论
我们需要更多证据来表明补充锌、镁和铁在治疗儿童ADHD中的作用。
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