Lee Jeonghwan, Lee Hajeong, Kim Kiwon, Park Jung Hwan, Kim Suhnggwon, Oh Jieun
Department of Internal Medicine, Hallym University Hangang Sacred Heart Hospital, Seoul, Korea.
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
J Korean Med Sci. 2014 Sep;29 Suppl 2(Suppl 2):S103-8. doi: 10.3346/jkms.2014.29.S2.S103. Epub 2014 Sep 30.
The relationship between salt intake and adequate blood pressure control is not well investigated in Korea populations, especially in patients with cardiovascular disease. This cross-sectional study enrolled 19,083 subjects who participated in the Korea National Health and Nutrition Examination Survey conducted from 2009-2011. The amount of salt intake was estimated using the Tanaka equations based on spot urine samples. Comparing patients with and without cardiovascular disease, systolic blood pressure (129.1±18.1 mmHg vs. 120.0±18.1 mmHg, P<0.001) and the amount of urinary sodium excretion (149.4±37.5 mM/day vs. 144.1±36.2 mM/day, P<0.001) were higher in patients with cardiovascular diseases. Among patients with cardiovascular disease, the high blood pressure group showed an increased amount of urinary sodium excretion compared to the normal blood pressure group (155.5±38.2 vs. 146.6±36.9 mM/day, P<0.001). The odds ratio (OR) of high blood pressure was higher (OR, 1.825; 95% CI, 1.187-2.807; P-for-trend 0.003, highest quartile of urinary sodium excretion vs. lowest quartile) in patients with cardiovascular disease. A higher amount of urinary sodium excretion was associated with a lower rate of adequate blood pressure control in Korean population, especially with cardiovascular disease.
在韩国人群中,尤其是心血管疾病患者中,盐摄入量与血压的充分控制之间的关系尚未得到充分研究。这项横断面研究纳入了19083名参与2009 - 2011年韩国国家健康与营养检查调查的受试者。基于即时尿样,使用田中方程估算盐摄入量。比较有心血管疾病和无心血管疾病的患者,有心血管疾病患者的收缩压(129.1±18.1 mmHg对120.0±18.1 mmHg,P<0.001)和尿钠排泄量(149.4±37.5 mM/天对144.1±36.2 mM/天,P<0.001)更高。在心血管疾病患者中,高血压组的尿钠排泄量比正常血压组增加(155.5±38.2对146.6±36.9 mM/天,P<0.001)。心血管疾病患者中高血压的比值比(OR)更高(OR,1.825;95%可信区间,1.187 - 2.807;趋势检验P值0.003,尿钠排泄量最高四分位数与最低四分位数相比)。在韩国人群中,尤其是患有心血管疾病的人群,尿钠排泄量越高,血压充分控制率越低。