Beach T G, Walker R, McGeer E G
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Glia. 1989;2(6):420-36. doi: 10.1002/glia.440020605.
The distribution of astrocytic gliosis in Alzheimer's disease (AD) and aging cerebrum, as marked by immunoperoxidase staining for glial fibrillary acidic protein (GFAP), was examined in whole-hemisphere coronal sections. Cortical gliosis in AD had an obvious laminar pattern. There were two heavy bands of staining, one in layers II-III and another in layer V. Normal aging cases sometimes displayed considerable cortical gliosis, but no specific patterns were apparent. Most AD cases, and some normal aging cases, displayed hypertrophy of immunoreactive astrocytes at grey matter-white matter interfaces, especially the cortico-medullary junction. Subcortical grey matter gliosis was common in both normal aging and AD, but there was no consistent pattern in either group. The deep cerebral white matter, which is stained evenly and heavily in young, healthy individuals, showed uneven staining in both normal elderly and AD brains. In both AD and aging, perivascular gliosis was prominent throughout the cerebrum and especially in the putamen. In conclusion, both AD and aging cerebri show extensive gliosis: AD cortical gliosis has a specific laminar pattern, but there does not appear to be an AD-specific pattern of subcortical gliosis.
通过对全脑半球冠状切片进行胶质纤维酸性蛋白（GFAP）免疫过氧化物酶染色，研究了阿尔茨海默病（AD）和衰老大脑中星形胶质细胞增生的分布情况。AD中的皮质胶质增生具有明显的分层模式。有两条染色浓重的带，一条在Ⅱ-Ⅲ层，另一条在Ⅴ层。正常衰老病例有时会出现相当程度的皮质胶质增生，但无明显的特定模式。大多数AD病例以及一些正常衰老病例在灰质-白质界面，尤其是皮质-髓质交界处，显示出免疫反应性星形胶质细胞肥大。皮质下灰质胶质增生在正常衰老和AD中均常见，但两组均无一致的模式。在年轻健康个体中均匀且浓重染色的大脑深部白质，在正常老年人和AD大脑中均显示出不均匀染色。在AD和衰老过程中，血管周围胶质增生在整个大脑中都很突出，尤其是在壳核中。总之，AD和衰老大脑均显示广泛的胶质增生：AD皮质胶质增生具有特定的分层模式，但皮质下胶质增生似乎没有AD特异性模式。
