Faghihimani Elham, Darakhshandeh Ali, Feizi Awat, Amini Masoud
Department of Internal Medicine, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Biostatistics and Epidemiology, School of Healh, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2014 Sep;5(9):1099-105.
The prevalence of prediabetes in the world continues to increase. These patients have elevated the risk of atherosclerosis. The current study was designed to assess the prevalence of peripheral arterial disease (PAD) and its related risk factors in prediabetes patients.
This was the case-control study in which 135 adults in three groups: Diabetes, prediabetes, and normal were studied. We evaluated the prevalence of PAD through the measurement of ankle-brachial index (ABI). All the patients were interviewed about demographic and medical data, including age, sex, disease duration, body mass index, hypertension (HTN), fasting blood glucose, hemoglobin A1C (HbA1C), lipid profile, and medication use.
The prevalence of PAD in diabetes patients was higher than the normal group (8.5%vs. 0.0%) (P < 0.05), but the differences between prediabetes compared with diabetes and normal group were not significant. The mean level of ABI in normal, prediabetes, and diabetes group was (1.11 ± 0.11), (1.09 ± 0.12), and (1.05 ± 0.03) respectively (P < 0.1). There were marginally significant differences of ABI observed between the normal group and the diabetes group. The observed differences between groups in the ABI were significant after adjusting the effects of age and sex (P < 0.05). There was an association observed between ABI and HbA1C in diabetes patients (r = 0.249, P < 0.01) and a significant association seen between PAD and HTN in the prediabetes group (P < 0.01).
Peripheral arterial disease is common in asymptomatic diabetes and prediabetes patients. Management of hypertensive prediabetes patients and early detection of PAD in this group as well as in asymptomatic patients is important.
世界上前驱糖尿病的患病率持续上升。这些患者患动脉粥样硬化的风险增加。本研究旨在评估前驱糖尿病患者外周动脉疾病（PAD）的患病率及其相关危险因素。
这是一项病例对照研究，对糖尿病组、前驱糖尿病组和正常组的135名成年人进行了研究。我们通过测量踝臂指数（ABI）评估PAD的患病率。所有患者均接受了关于人口统计学和医学数据的访谈，包括年龄、性别、病程、体重指数、高血压（HTN）、空腹血糖、糖化血红蛋白（HbA1C）、血脂谱和用药情况。
糖尿病患者中PAD的患病率高于正常组（8.5%对0.0%）（P<0.05），但前驱糖尿病组与糖尿病组和正常组之间的差异不显著。正常组、前驱糖尿病组和糖尿病组的平均ABI水平分别为（1.11±0.11）、（1.09±0.12）和（1.05±0.03）（P<0.1）。正常组和糖尿病组之间观察到ABI有微小显著差异。在调整年龄和性别的影响后，各组之间观察到的ABI差异具有统计学意义（P<0.05）。糖尿病患者中观察到ABI与HbA1C之间存在关联（r=0.249，P<0.01），前驱糖尿病组中观察到PAD与HTN之间存在显著关联（P<0.01）。
外周动脉疾病在无症状糖尿病和前驱糖尿病患者中很常见。管理高血压前驱糖尿病患者并在该组以及无症状患者中早期发现PAD很重要。
